PDF(Pubmed)
Abstract：
BACKGROUND: Previous studies have raised concerns regarding neurodevelopmental impacts of early exposures to general anesthesia and surgery. Electroencephalography (EEG) can be used to study ontogeny of brain networks during infancy. As a substudy of an ongoing study, we examined measures of functional connectivity in awake infants with prior early and prolonged anesthetic exposures and in control infants.
METHODS: EEG functional connectivity was assessed using debiased weighted phase lag index at source and sensor levels and graph theoretical measures for resting state activity in awake infants in the early anesthesia (n = 26 at 10 month visit, median duration of anesthesia = 4 [2, 7 h]) and control (n = 38 at 10 month visit) groups at ages approximately 2, 4 and 10 months. Theta and low alpha frequency bands were of primary interest. Linear mixed models incorporated impact of age and cumulative hours of general anesthesia exposure.
RESULTS: Models showed no significant impact of cumulative hours of general anesthesia exposure on debiased weighted phase lag index, characteristic path length, clustering coefficient or small-worldness (conditional R2 0.05-0.34). An effect of age was apparent in many of these measures.
CONCLUSIONS: We could not demonstrate significant impact of general anesthesia in the first months of life on early development of resting state brain networks over the first postnatal year. Future studies will explore these networks as these infants grow older.
METHODS: EEG functional connectivity was assessed using debiased weighted phase lag index at source and sensor levels and graph theoretical measures for resting state activity in awake infants in the early anesthesia (n = 26 at 10 month visit, median duration of anesthesia = 4 [2, 7 h]) and control (n = 38 at 10 month visit) groups at ages approximately 2, 4 and 10 months. Theta and low alpha frequency bands were of primary interest. Linear mixed models incorporated impact of age and cumulative hours of general anesthesia exposure.
RESULTS: Models showed no significant impact of cumulative hours of general anesthesia exposure on debiased weighted phase lag index, characteristic path length, clustering coefficient or small-worldness (conditional R2 0.05-0.34). An effect of age was apparent in many of these measures.
CONCLUSIONS: We could not demonstrate significant impact of general anesthesia in the first months of life on early development of resting state brain networks over the first postnatal year. Future studies will explore these networks as these infants grow older.
摘要：
背景：先前的研究已经引起了对全身麻醉和手术早期暴露对神经发育影响的担忧。脑电图（EEG）可用于研究婴儿期脑网络的个体发育。作为一项正在进行的研究的子研究，我们检测了早期和长期使用麻醉药的清醒婴儿和对照婴儿的功能连接指标.
方法：使用源和传感器水平的去偏性加权相位滞后指数以及麻醉早期清醒婴儿静息状态活动的图形理论测量来评估EEG功能连通性（10个月访视时n=26，中位麻醉持续时间=4[2，7h]）和对照组（n=38，10个月访视），年龄约为2、4和10个月。θ和低α频带是主要感兴趣的。线性混合模型纳入了年龄和全身麻醉暴露累积小时数的影响。
结果：模型显示，全身麻醉暴露的累积小时数对去偏性加权相位滞后指数没有显着影响，特征路径长度,聚类系数或小世界(条件R20.05-0.34)。在许多这些措施中，年龄的影响是显而易见的。
结论：我们无法证明出生后第一个月的全身麻醉对出生后第一个年静息状态脑网络早期发育的显著影响。未来的研究将随着这些婴儿年龄的增长而探索这些网络。
方法：使用源和传感器水平的去偏性加权相位滞后指数以及麻醉早期清醒婴儿静息状态活动的图形理论测量来评估EEG功能连通性（10个月访视时n=26，中位麻醉持续时间=4[2，7h]）和对照组（n=38，10个月访视），年龄约为2、4和10个月。θ和低α频带是主要感兴趣的。线性混合模型纳入了年龄和全身麻醉暴露累积小时数的影响。
结果：模型显示，全身麻醉暴露的累积小时数对去偏性加权相位滞后指数没有显着影响，特征路径长度,聚类系数或小世界(条件R20.05-0.34)。在许多这些措施中，年龄的影响是显而易见的。
结论：我们无法证明出生后第一个月的全身麻醉对出生后第一个年静息状态脑网络早期发育的显著影响。未来的研究将随着这些婴儿年龄的增长而探索这些网络。
