Abstract：
Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.
摘要：
单克隆IgM的肾小球沉积,通常以毛细血管内假性血栓的形式，可见于Waldenström巨球蛋白血症（WM）和I型冷球蛋白血症（CG）。它们通常与浆细胞或B淋巴样肿瘤有关，特别是淋巴浆细胞性淋巴瘤（LPL）。虽然感染是混合（II型和III型）CG的常见触发因素，其与I型CG的关联并不常见。我们报告了2例，在已知或可疑的全身性感染中，发生了明显的λ链限制性IgM沉积物和急性肾损伤（AKI）。迅速解决感染的治疗。
