%0 Case Reports
%T Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins.
%A Wang B
%A Schub M
%A Robinson DL
%A Howell DN
%J Ultrastruct Pathol
%V 48
%N 4
%D 2024 Jul 3
%M 38752567
%F 1.385
%R 10.1080/01913123.2024.2356112
%X Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.