{Reference Type}: Case Reports
{Title}: Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins.
{Author}: Wang B;Schub M;Robinson DL;Howell DN;
{Journal}: Ultrastruct Pathol
{Volume}: 48
{Issue}: 4
{Year}: 2024 Jul 3
{Factor}: 1.385
{DOI}: 10.1080/01913123.2024.2356112
{Abstract}: Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.