使用脂肪基质或干细胞衍生的类器官模拟人类酒精相关肝病。
关键词: ALD CP: Stem cell alcohol fibrosis hepatocellular organoid human adipose stromal/stem cells liver organoid steatosis
Mesh : Humans Organoids / pathology drug effects Ethanol / pharmacology adverse effects Liver Diseases, Alcoholic / pathology metabolism Hepatocytes / drug effects pathology metabolism Adipose Tissue / pathology cytology Alcohol Dehydrogenase / metabolism Oxidative Stress / drug effects Liver / pathology drug effects metabolism Stem Cells / drug effects metabolism pathology Models, Biological Aldehyde Dehydrogenase 1 Family / metabolism genetics Stromal Cells / pathology drug effects metabolism Thioredoxins / metabolism
来 源:
DOI:10.1016/j.crmeth.2024.100778
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