PDF(Pubmed)
Abstract：
BACKGROUND: Asia consists of diverse nations with extremely variable health care systems. Integrated real-world data (RWD) research warehouses provide vast interconnected data sets that uphold statistical rigor. Yet, their intricate details remain underexplored, restricting their broader applications.
OBJECTIVE: Building on our previous research that analyzed integrated RWD warehouses in India, Thailand, and Taiwan, this study extends the research to 7 distinct health care systems: Hong Kong, Indonesia, Malaysia, Pakistan, the Philippines, Singapore, and Vietnam. We aimed to map the evolving landscape of RWD, preferences for methodologies, and database use and archetype the health systems based on existing intrinsic capability for RWD generation.
METHODS: A systematic scoping review methodology was used, centering on contemporary English literature on PubMed (search date: May 9, 2023). Rigorous screening as defined by eligibility criteria identified RWD studies from multiple health care facilities in at least 1 of the 7 target Asian nations. Point estimates and their associated errors were determined for the data collected from eligible studies.
RESULTS: Of the 1483 real-world evidence citations identified on May 9, 2023, a total of 369 (24.9%) fulfilled the requirements for data extraction and subsequent analysis. Singapore, Hong Kong, and Malaysia contributed to ≥100 publications, with each country marked by a higher proportion of single-country studies at 51% (80/157), 66.2% (86/130), and 50% (50/100), respectively, and were classified as solo scholars. Indonesia, Pakistan, Vietnam, and the Philippines had fewer publications and a higher proportion of cross-country collaboration studies (CCCSs) at 79% (26/33), 58% (18/31), 74% (20/27), and 86% (19/22), respectively, and were classified as global collaborators. Collaboration with countries outside the 7 target nations appeared in 84.2% to 97.7% of the CCCSs of each nation. Among target nations, Singapore and Malaysia emerged as preferred research partners for other nations. From 2018 to 2023, most nations showed an increasing trend in study numbers, with Vietnam (24.5%) and Pakistan (21.2%) leading the growth; the only exception was the Philippines, which declined by -14.5%. Clinical registry databases were predominant across all CCCSs from every target nation. For single-country studies, Indonesia, Malaysia, and the Philippines favored clinical registries; Singapore had a balanced use of clinical registries and electronic medical or health records, whereas Hong Kong, Pakistan, and Vietnam leaned toward electronic medical or health records. Overall, 89.9% (310/345) of the studies took >2 years from completion to publication.
CONCLUSIONS: The observed variations in contemporary RWD publications across the 7 nations in Asia exemplify distinct research landscapes across nations that are partially explained by their diverse economic, clinical, and research settings. Nevertheless, recognizing these variations is pivotal for fostering tailored, synergistic strategies that amplify RWD\'s potential in guiding future health care research and policy decisions.
UNASSIGNED: RR2-10.2196/43741.
OBJECTIVE: Building on our previous research that analyzed integrated RWD warehouses in India, Thailand, and Taiwan, this study extends the research to 7 distinct health care systems: Hong Kong, Indonesia, Malaysia, Pakistan, the Philippines, Singapore, and Vietnam. We aimed to map the evolving landscape of RWD, preferences for methodologies, and database use and archetype the health systems based on existing intrinsic capability for RWD generation.
METHODS: A systematic scoping review methodology was used, centering on contemporary English literature on PubMed (search date: May 9, 2023). Rigorous screening as defined by eligibility criteria identified RWD studies from multiple health care facilities in at least 1 of the 7 target Asian nations. Point estimates and their associated errors were determined for the data collected from eligible studies.
RESULTS: Of the 1483 real-world evidence citations identified on May 9, 2023, a total of 369 (24.9%) fulfilled the requirements for data extraction and subsequent analysis. Singapore, Hong Kong, and Malaysia contributed to ≥100 publications, with each country marked by a higher proportion of single-country studies at 51% (80/157), 66.2% (86/130), and 50% (50/100), respectively, and were classified as solo scholars. Indonesia, Pakistan, Vietnam, and the Philippines had fewer publications and a higher proportion of cross-country collaboration studies (CCCSs) at 79% (26/33), 58% (18/31), 74% (20/27), and 86% (19/22), respectively, and were classified as global collaborators. Collaboration with countries outside the 7 target nations appeared in 84.2% to 97.7% of the CCCSs of each nation. Among target nations, Singapore and Malaysia emerged as preferred research partners for other nations. From 2018 to 2023, most nations showed an increasing trend in study numbers, with Vietnam (24.5%) and Pakistan (21.2%) leading the growth; the only exception was the Philippines, which declined by -14.5%. Clinical registry databases were predominant across all CCCSs from every target nation. For single-country studies, Indonesia, Malaysia, and the Philippines favored clinical registries; Singapore had a balanced use of clinical registries and electronic medical or health records, whereas Hong Kong, Pakistan, and Vietnam leaned toward electronic medical or health records. Overall, 89.9% (310/345) of the studies took >2 years from completion to publication.
CONCLUSIONS: The observed variations in contemporary RWD publications across the 7 nations in Asia exemplify distinct research landscapes across nations that are partially explained by their diverse economic, clinical, and research settings. Nevertheless, recognizing these variations is pivotal for fostering tailored, synergistic strategies that amplify RWD\'s potential in guiding future health care research and policy decisions.
UNASSIGNED: RR2-10.2196/43741.
摘要：
背景：亚洲由不同的国家组成，医疗保健系统和社会经济错综复杂。集成的现实世界数据（RWD）研究仓库提供了大量互连的数据集，这些数据集保持了统计的严谨性。然而,他们错综复杂的细节仍然没有得到充分的探索，限制了它们在医疗保健研究中的广泛应用，政策和伙伴关系。
目标：基于我们先前的研究，分析了印度的RWD综合仓库，泰国和台湾,这项研究是对七个不同的亚洲医疗保健系统的扩展：香港，印度尼西亚,马来西亚,巴基斯坦,菲律宾,新加坡,和越南。我们的目标是绘制RWD使用的演变格局，阐明从集成数据库生成真实世界证据(RWE)的当前状态，并了解RWD方法和数据库使用的不断发展的偏好。
方法：：采用系统范围审查方法，以PubMed上的当代英语文献检索为中心(检索日期：2023年5月9日)。严格的筛查遵循定义的资格标准，以利用来自七个目标亚洲国家中至少一个的多个医疗机构的综合RWD来确定研究。没有为结果的描述建立统计假设。从符合条件的研究中收集的数据确定了点估计及其相关误差。
结果：在2023年5月9日确定的1483个RWE研究标题中，有369个（24.9％）满足了数据提取和后续分析的要求。新加坡,香港,马来西亚贡献了100多种出版物，每个标志着更高的SCS比例为51%(80/157)，66.2%（86/130），和50%（50/100），分别,被列为独奏学者。印度尼西亚,巴基斯坦,越南和菲律宾的出版物较少，CCCS的比例较高，为78.8％（26/33），58.1%（18/31），74.1%(20/27)，和86.4%(19/22)，分别被归类为全球合作者。与七个目标国家以外的国家的合作出现在每个国家的CCCS的84.2％-97.7％。在目标国家中，新加坡和马来西亚成为其他国家的首选研究伙伴。从2018年到2023年，大多数国家的研究数量呈增长趋势，越南（24.5%）和巴基斯坦（21.2%）引领增长；唯一的例外是菲律宾，下降了-14.5%。临床注册数据库在来自每个目标国家的所有CCCS中占主导地位。对于SCS，印度尼西亚,马来西亚,菲律宾赞成临床登记处；新加坡平衡使用临床登记处和EMR/EHR，而香港,巴基斯坦,越南向EMR/EHR倾斜。超过90%的研究从完成到发表花了超过2年的时间。
结论：在亚洲7个国家的当代RWD出版物中观察到的差异体现了各国不同的研究景观，这些研究景观部分由其多样化的经济解释，临床,和研究环境。然而，认识到这些变化是培养量身定制的关键，增强RWD在指导未来医疗保健研究和政策决策方面潜力的协同策略。
背景：
目标：基于我们先前的研究，分析了印度的RWD综合仓库，泰国和台湾,这项研究是对七个不同的亚洲医疗保健系统的扩展：香港，印度尼西亚,马来西亚,巴基斯坦,菲律宾,新加坡,和越南。我们的目标是绘制RWD使用的演变格局，阐明从集成数据库生成真实世界证据(RWE)的当前状态，并了解RWD方法和数据库使用的不断发展的偏好。
方法：：采用系统范围审查方法，以PubMed上的当代英语文献检索为中心(检索日期：2023年5月9日)。严格的筛查遵循定义的资格标准，以利用来自七个目标亚洲国家中至少一个的多个医疗机构的综合RWD来确定研究。没有为结果的描述建立统计假设。从符合条件的研究中收集的数据确定了点估计及其相关误差。
结果：在2023年5月9日确定的1483个RWE研究标题中，有369个（24.9％）满足了数据提取和后续分析的要求。新加坡,香港,马来西亚贡献了100多种出版物，每个标志着更高的SCS比例为51%(80/157)，66.2%（86/130），和50%（50/100），分别,被列为独奏学者。印度尼西亚,巴基斯坦,越南和菲律宾的出版物较少，CCCS的比例较高，为78.8％（26/33），58.1%（18/31），74.1%(20/27)，和86.4%(19/22)，分别被归类为全球合作者。与七个目标国家以外的国家的合作出现在每个国家的CCCS的84.2％-97.7％。在目标国家中，新加坡和马来西亚成为其他国家的首选研究伙伴。从2018年到2023年，大多数国家的研究数量呈增长趋势，越南（24.5%）和巴基斯坦（21.2%）引领增长；唯一的例外是菲律宾，下降了-14.5%。临床注册数据库在来自每个目标国家的所有CCCS中占主导地位。对于SCS，印度尼西亚,马来西亚,菲律宾赞成临床登记处；新加坡平衡使用临床登记处和EMR/EHR，而香港,巴基斯坦,越南向EMR/EHR倾斜。超过90%的研究从完成到发表花了超过2年的时间。
结论：在亚洲7个国家的当代RWD出版物中观察到的差异体现了各国不同的研究景观，这些研究景观部分由其多样化的经济解释，临床,和研究环境。然而，认识到这些变化是培养量身定制的关键，增强RWD在指导未来医疗保健研究和政策决策方面潜力的协同策略。
背景：
