Abstract：
This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.
摘要：
本研究通过调查3D打印剂型的利用来探索个性化医疗的领域，特别是针对患者特定的肠溶胶囊，设计用于酮洛芬的调节释放，作为示范药物。该研究调查了两种不同的情况：从羟丙基甲基纤维素邻苯二甲酸酯制成的3D打印胶囊中药物释放的改变：聚乙二醇（HPMCP：PEG）和聚（乙烯醇）（PVA），为pH敏感性和延迟释放模式量身定制，分别。此外,开发了一种基于石榴籽油（PSO）的新型酮洛芬自纳米乳化给药系统（SNEDDS），characterized,并用作胶囊的填充材料。通过热熔挤出法制备和表征HPMCP:PEG基长丝,这项研究彻底调查了它的热和机械性能。值得注意的是,体外药物释放分析揭示了酮洛芬释放之间复杂的相互作用，聚合物类型,和胶囊厚度。此外，将酮洛芬掺入SNEDDS中表现出其体外环氧化酶2（COX-2）抑制活性的增强。这些发现共同强调了3D打印在塑造定制药物输送系统方面的潜力。从而为个性化医疗的进步做出了重大贡献。
