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Abstract：
BACKGROUND: While some evidence suggests that l-arginine may improve sexual function and alleviate depression, it has not been investigated in women with depression to assess both its effects on the depression and sexual function concurrently.
METHODS: Patients who had received a diagnosis of major depressive disorder, as determined by predetermined inclusion and exclusion criteria, were enrolled in this triple-blind clinical trial. Patients were divided into two groups: group A, received L-arginine 1 gram twice daily, and group B, received a placebo for four weeks. They were evaluated at baseline, after four and eight weeks with the Hamilton Depression Rating Scale (HDRS), and Rosen\'s questionnaire or Female Sexual Function Index (FSFI).
RESULTS: A decrease in the severity of depression was observed in all patients, which was determined due to Hamilton\'s questionnaire (P-value < 0.001). During the time in group A, FSFI increased. Based on the FSFI questionnaire, they had improvement in some domains, including the lubrication index and orgasm index, which significantly changed in the eighth week compared to the baseline (P-value < 0.05). However, these two indicators did not change statistically significantly compared to the placebo group.
CONCLUSIONS: L-arginine supplementation can improve sexual function, particularly lubrication and orgasm, and mood in women with depression, with minimal side effects observed. Additional research is necessary to validate these results by examining the effects of higher dosages, extended durations, and larger populations of depressed patients.
BACKGROUND: Iranian Registry of Clinical Trial: IRCT20100127003210N26.
METHODS: Patients who had received a diagnosis of major depressive disorder, as determined by predetermined inclusion and exclusion criteria, were enrolled in this triple-blind clinical trial. Patients were divided into two groups: group A, received L-arginine 1 gram twice daily, and group B, received a placebo for four weeks. They were evaluated at baseline, after four and eight weeks with the Hamilton Depression Rating Scale (HDRS), and Rosen\'s questionnaire or Female Sexual Function Index (FSFI).
RESULTS: A decrease in the severity of depression was observed in all patients, which was determined due to Hamilton\'s questionnaire (P-value < 0.001). During the time in group A, FSFI increased. Based on the FSFI questionnaire, they had improvement in some domains, including the lubrication index and orgasm index, which significantly changed in the eighth week compared to the baseline (P-value < 0.05). However, these two indicators did not change statistically significantly compared to the placebo group.
CONCLUSIONS: L-arginine supplementation can improve sexual function, particularly lubrication and orgasm, and mood in women with depression, with minimal side effects observed. Additional research is necessary to validate these results by examining the effects of higher dosages, extended durations, and larger populations of depressed patients.
BACKGROUND: Iranian Registry of Clinical Trial: IRCT20100127003210N26.
摘要：
背景：虽然一些证据表明L-精氨酸可以改善性功能和缓解抑郁症，尚未在患有抑郁症的女性中进行调查，以同时评估其对抑郁症和性功能的影响。
方法：被诊断为重度抑郁症的患者，根据预定的纳入和排除标准确定，参加了这项三盲临床试验。患者分为两组：A组，每天两次服用L-精氨酸1克，B组,服用安慰剂4周。他们在基线时进行了评估，在使用汉密尔顿抑郁量表（HDRS）进行四周和八周后，和罗森的问卷或女性性功能指数(FSFI)。
结果：在所有患者中观察到抑郁症的严重程度有所下降，这是根据汉密尔顿的问卷确定的(P值<0.001)。在A组的时间里,FSFI增加。根据FSFI问卷，他们在某些领域有所改善，包括润滑指数和性高潮指数,与基线相比，第8周显着变化（P值<0.05）。然而,与安慰剂组相比,这两项指标无统计学差异.
结论：补充L-精氨酸可以改善性功能，特别是润滑和性高潮，抑郁症女性的情绪，观察到最小的副作用。额外的研究是必要的，以验证这些结果，通过检查更高的剂量的影响，延长的持续时间，和更多的抑郁症患者。
背景：伊朗临床试验注册：IRCT20100127003210N26。
方法：被诊断为重度抑郁症的患者，根据预定的纳入和排除标准确定，参加了这项三盲临床试验。患者分为两组：A组，每天两次服用L-精氨酸1克，B组,服用安慰剂4周。他们在基线时进行了评估，在使用汉密尔顿抑郁量表（HDRS）进行四周和八周后，和罗森的问卷或女性性功能指数(FSFI)。
结果：在所有患者中观察到抑郁症的严重程度有所下降，这是根据汉密尔顿的问卷确定的(P值<0.001)。在A组的时间里,FSFI增加。根据FSFI问卷，他们在某些领域有所改善，包括润滑指数和性高潮指数,与基线相比，第8周显着变化（P值<0.05）。然而,与安慰剂组相比,这两项指标无统计学差异.
结论：补充L-精氨酸可以改善性功能，特别是润滑和性高潮，抑郁症女性的情绪，观察到最小的副作用。额外的研究是必要的，以验证这些结果，通过检查更高的剂量的影响，延长的持续时间，和更多的抑郁症患者。
背景：伊朗临床试验注册：IRCT20100127003210N26。
