METHODS: Using functional magnetic resonance imaging, two sessions were conducted focusing on the anticipation and receipt of monetary reward (1) or loss (2), each contrasted to a verbal (control) condition. In each session, adolescents with OCD (n1=31/n2=26) were compared with typically developing (TD) controls (n1=33/ n2=31), all aged 10-19 years, during the anticipation and feedback phase of an adapted Monetary Incentive Delay task.
RESULTS: Data revealed a hyperactivation of the VS, but not the OFC, when anticipating both monetary reward and loss in the OCD compared to the TD group.
CONCLUSIONS: These findings suggest that aberrant neural reward and loss processing in OCD is associated with greater motivation to gain or maintain a reward but not with the actual receipt. The greater degree of reward \'wanting\' may contribute to adolescents with OCD repeating certain actions more and more frequently, which then become habits (i.e., OCD symptomatology).
方法:使用功能磁共振成像,举行了两次会议,重点是金钱奖励(1)或损失(2)的预期和接收,每个都与口头(控制)条件形成对比。在每个会话中,将患有强迫症的青少年(n1=31/n2=26)与典型发展中(TD)对照(n1=33/n2=31)进行比较,都是10-19岁,在适应性货币激励延迟任务的预期和反馈阶段。
结果:数据显示VS过度激活,但不是OFC,与TD组相比,当预期强迫症的金钱回报和损失时。
结论:这些发现表明,强迫症中异常的神经奖励和损失处理与获得或维持奖励的更大动机有关,但与实际接收无关。更大程度的奖励“想要”可能会导致患有强迫症的青少年越来越频繁地重复某些行为,然后成为习惯(即,强迫症症状)。