Abstract：
Unscheduled bleeding on hormone replacement therapy (HRT) can affect up to 40% of users. In parallel with the increase in HRT prescribing in the UK, there has been an associated increase in referrals to the urgent suspicion of cancer pathway for unscheduled bleeding. On behalf of the British Menopause Society (BMS) an expert review panel was established, including primary and secondary care clinicians with expertise in the management of menopause, with representatives from key related organisations, including the Royal College of Obstetricians & Gynaecologists, the British Gynaecological Cancer Society, British Society for Gynaecological Endoscopy, Royal College of General Practitioners and Faculty of Sexual and Reproductive Health, and service development partners from NHS England and GIRFT (Getting it Right First Time). For each topic, a focused literature review was completed to develop evidence led recommendations, where available, which were ratified by consensus review within the panel and by guideline groups.
摘要：
激素替代疗法（HRT）的计划外出血可能会影响多达40％的用户。在英国增加HRT处方的同时，与因计划外出血而对癌症途径的紧急怀疑相关的转诊增加.代表英国更年期协会（BMS）成立了一个专家审查小组，包括具有更年期管理专业知识的初级和二级保健临床医生，与主要相关组织的代表，包括皇家妇产科学院,英国妇科癌症协会,英国妇科内窥镜学会，皇家全科医师学院和性健康与生殖健康学院，以及NHS英格兰和GIRFT的服务开发合作伙伴（首次正确）。对于每个主题，完成了重点文献综述，以制定证据引导的建议，如果可用，通过小组内部和准则小组的共识审查批准了这些文件。
