Abstract：
UNASSIGNED: In temporal bone specimens from long-term cochlear implant users, foreign body response within the cochlea has been demonstrated. However, how hearing changes after implantation and fibrosis progresses within the cochlea is unknown.
UNASSIGNED: To investigate the short-term dynamic changes in hearing and cochlear histopathology in minipigs after electrode array insertion.
UNASSIGNED: Twelve minipigs were selected for electrode array insertion (EAI) and the Control. Hearing tests were performed preoperatively and on 0, 7, 14, and 28 day(s) postoperatively, and cochlear histopathology was performed after the hearing tests on 7, 14, and 28 days after surgery.
UNASSIGNED: Electrode array insertion had a significant effect for the frequency range tested (1 kHz-20kHz). Exudation was evident one week after electrode array insertion; at four weeks postoperatively, a fibrous sheath formed around the electrode. At each time point, the endolymphatic hydrops was found; no significant changes in the morphology and packing density of the spiral ganglion neurons were observed.
UNASSIGNED: The effect of electrode array insertion on hearing and intracochlear fibrosis was significant. The process of fibrosis and endolymphatic hydrops seemed to not correlate with the degree of hearing loss, nor did it affect spiral ganglion neuron integrity in the 4-week postoperative period.
UNASSIGNED: To investigate the short-term dynamic changes in hearing and cochlear histopathology in minipigs after electrode array insertion.
UNASSIGNED: Twelve minipigs were selected for electrode array insertion (EAI) and the Control. Hearing tests were performed preoperatively and on 0, 7, 14, and 28 day(s) postoperatively, and cochlear histopathology was performed after the hearing tests on 7, 14, and 28 days after surgery.
UNASSIGNED: Electrode array insertion had a significant effect for the frequency range tested (1 kHz-20kHz). Exudation was evident one week after electrode array insertion; at four weeks postoperatively, a fibrous sheath formed around the electrode. At each time point, the endolymphatic hydrops was found; no significant changes in the morphology and packing density of the spiral ganglion neurons were observed.
UNASSIGNED: The effect of electrode array insertion on hearing and intracochlear fibrosis was significant. The process of fibrosis and endolymphatic hydrops seemed to not correlate with the degree of hearing loss, nor did it affect spiral ganglion neuron integrity in the 4-week postoperative period.
摘要：
■在长期人工耳蜗使用者的颞骨标本中，耳蜗内的异物反应已得到证实。然而,植入后的听力变化和纤维化在耳蜗内的进展是未知的。
■研究电极阵列插入后小型猪的听力和耳蜗组织病理学的短期动态变化。
■选择12只小型猪进行电极阵列插入(EAI)和对照。听力测试在术前和术后第0、7、14和28天进行，术后7、14和28天进行听力检查后进行耳蜗组织病理学检查。
■电极阵列插入对测试的频率范围（1kHz-20kHz）具有显着影响。电极阵列插入后一周，渗出明显；术后四周，在电极周围形成的纤维鞘。在每个时间点,发现了内淋巴积水；未观察到螺旋神经节神经元的形态和堆积密度的显着变化。
■电极阵列插入对听力和耳蜗内纤维化的影响显着。纤维化和内淋巴积液的过程似乎与听力损失的程度无关，在术后4周期间，它也不影响螺旋神经节神经元的完整性。
■研究电极阵列插入后小型猪的听力和耳蜗组织病理学的短期动态变化。
■选择12只小型猪进行电极阵列插入(EAI)和对照。听力测试在术前和术后第0、7、14和28天进行，术后7、14和28天进行听力检查后进行耳蜗组织病理学检查。
■电极阵列插入对测试的频率范围（1kHz-20kHz）具有显着影响。电极阵列插入后一周，渗出明显；术后四周，在电极周围形成的纤维鞘。在每个时间点,发现了内淋巴积水；未观察到螺旋神经节神经元的形态和堆积密度的显着变化。
■电极阵列插入对听力和耳蜗内纤维化的影响显着。纤维化和内淋巴积液的过程似乎与听力损失的程度无关，在术后4周期间，它也不影响螺旋神经节神经元的完整性。
