PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have highlighted associations between certain inflammatory cytokines and Ménière\'s Disease (MD), such as interleukin (IL) -13 and IL-1β. This Mendelian randomization aims to comprehensively evaluate the causal relationships between 91 inflammatory cytokines and MD.
UNASSIGNED: A comprehensive two-sample Mendelian randomization (MR) analysis was conducted to determine the causal association between inflammatory cytokines and MD. Utilizing publicly accessible genetic datasets, we explored causal links between 91 inflammatory cytokines and MD risk. Comprehensive sensitivity analyses were employed to assess the robustness, heterogeneity, and presence of horizontal pleiotropy in our findings.
UNASSIGNED: Our findings indicate that MD causally influences the levels of two cytokine types: IL-10 (P=0.048, OR=0.945, 95%CI =0.894~1.000) and Neurotrophin-3 (P=0.045, OR=0954, 95%CI =0.910~0.999). Furthermore, three cytokines exhibited significant causal effects on MD: CD40L receptor (P=0.008, OR=0.865, 95%CI =0.777-0.963), Delta and Notch-like epidermal growth factor-related receptor (DNER) (P=0.010, OR=1.216, 95%CI =1.048-1.412), and STAM binding protein (P=0.044, OR=0.776, 95%CI =0.606-0.993).
UNASSIGNED: This study suggests that the CD40L receptor, DNER, and STAM binding protein could potentially serve as upstream determinants of MD. Furthermore, our results imply that when MD is regarded as the exposure variable in MR analysis, it may causally correlate with elevated levels of IL-10 and Neurotrophin-3. Using these cytokines for MD diagnosis or as potential therapeutic targets holds great clinical significance.
UNASSIGNED: A comprehensive two-sample Mendelian randomization (MR) analysis was conducted to determine the causal association between inflammatory cytokines and MD. Utilizing publicly accessible genetic datasets, we explored causal links between 91 inflammatory cytokines and MD risk. Comprehensive sensitivity analyses were employed to assess the robustness, heterogeneity, and presence of horizontal pleiotropy in our findings.
UNASSIGNED: Our findings indicate that MD causally influences the levels of two cytokine types: IL-10 (P=0.048, OR=0.945, 95%CI =0.894~1.000) and Neurotrophin-3 (P=0.045, OR=0954, 95%CI =0.910~0.999). Furthermore, three cytokines exhibited significant causal effects on MD: CD40L receptor (P=0.008, OR=0.865, 95%CI =0.777-0.963), Delta and Notch-like epidermal growth factor-related receptor (DNER) (P=0.010, OR=1.216, 95%CI =1.048-1.412), and STAM binding protein (P=0.044, OR=0.776, 95%CI =0.606-0.993).
UNASSIGNED: This study suggests that the CD40L receptor, DNER, and STAM binding protein could potentially serve as upstream determinants of MD. Furthermore, our results imply that when MD is regarded as the exposure variable in MR analysis, it may causally correlate with elevated levels of IL-10 and Neurotrophin-3. Using these cytokines for MD diagnosis or as potential therapeutic targets holds great clinical significance.
摘要：
■先前的研究强调了某些炎性细胞因子与梅尼埃病（MD）之间的关联。如白细胞介素(IL)-13和IL-1β。孟德尔随机化旨在全面评估91种炎性细胞因子与MD之间的因果关系。
■进行了全面的双样本孟德尔随机化（MR）分析，以确定炎性细胞因子与MD之间的因果关系。利用可公开访问的遗传数据集，我们探讨了91种炎性细胞因子与MD风险之间的因果关系.采用综合敏感性分析来评估稳健性，异质性，以及我们发现中存在水平多效性。
■我们的研究结果表明，MD对两种细胞因子的水平有因果关系：IL-10（P=0.048，OR=0.945，95CI=0.894〜1.000）和Neurotrophin-3（P=0.045，OR=0954，95CI=0.910〜0.999）。此外，三种细胞因子对MD表现出显著的因果效应:CD40L受体(P=0.008,OR=0.865,95CI=0.777-0.963),δ和Notch样表皮生长因子相关受体(DNER)(P=0.010,OR=1.216,95CI=1.048-1.412),STAM结合蛋白(P=0.044,OR=0.776,95CI=0.606-0.993)。
■这项研究表明，CD40L受体，DNER,和STAM结合蛋白可能作为MD的上游决定因素。此外，我们的结果表明，当MD被视为MR分析中的暴露变量时，它可能与IL-10和神经营养蛋白-3水平升高有因果关系。使用这些细胞因子进行MD诊断或作为潜在的治疗靶标具有重要的临床意义。
■进行了全面的双样本孟德尔随机化（MR）分析，以确定炎性细胞因子与MD之间的因果关系。利用可公开访问的遗传数据集，我们探讨了91种炎性细胞因子与MD风险之间的因果关系.采用综合敏感性分析来评估稳健性，异质性，以及我们发现中存在水平多效性。
■我们的研究结果表明，MD对两种细胞因子的水平有因果关系：IL-10（P=0.048，OR=0.945，95CI=0.894〜1.000）和Neurotrophin-3（P=0.045，OR=0954，95CI=0.910〜0.999）。此外，三种细胞因子对MD表现出显著的因果效应:CD40L受体(P=0.008,OR=0.865,95CI=0.777-0.963),δ和Notch样表皮生长因子相关受体(DNER)(P=0.010,OR=1.216,95CI=1.048-1.412),STAM结合蛋白(P=0.044,OR=0.776,95CI=0.606-0.993)。
■这项研究表明，CD40L受体，DNER,和STAM结合蛋白可能作为MD的上游决定因素。此外，我们的结果表明，当MD被视为MR分析中的暴露变量时，它可能与IL-10和神经营养蛋白-3水平升高有因果关系。使用这些细胞因子进行MD诊断或作为潜在的治疗靶标具有重要的临床意义。
