PDF(Pubmed)
Abstract：
In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western cohorts. We conducted a retrospective analysis of an unselected Middle Eastern cohort of newly diagnosed CLL patients seen at the Kuwait Cancer Control Center (n = 300). Compared to Western studies, these Middle Eastern patients were diagnosed at a younger age (median of 59) and had a higher comorbidity burden (69% non-low risk CLL-CI). A higher CLL-CI score was independently associated with significantly shorter event-free survival and greater risk of death. Our analysis demonstrates that CLL-CI is a valuable tool for comorbidity assessment and prognostic influence in (relatively young) Middle Eastern CLL patients.
摘要：
在慢性淋巴细胞白血病（CLL）中，在西方队列中,通过CLL合并症指数(CLL-CI)评估的合并症与结局相关.我们对在科威特癌症控制中心（n=300）看到的未选择的中东新诊断CLL患者队列进行了回顾性分析。与西方研究相比，这些中东患者的诊断年龄较小(中位数为59岁),且合并症负担较高(69%非低危CLL-CI).较高的CLL-CI评分与显著缩短的无事件生存期和更高的死亡风险独立相关。我们的分析表明，CLL-CI是（相对年轻的）中东CLL患者合并症评估和预后影响的有价值的工具。
