{Reference Type}: Journal Article
{Title}: Prognostic impact of chronic lymphocytic leukemia comorbidity index in a young population: a real-world evidence study of a national gulf region cohort.
{Author}: Alshemmari SH;AlSarraf A;Kaempf A;Danilov AV;
{Journal}: BMC Cancer
{Volume}: 24
{Issue}: 1
{Year}: 2024 May 13
{Factor}: 4.638
{DOI}: 10.1186/s12885-024-12343-1
{Abstract}: In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western cohorts. We conducted a retrospective analysis of an unselected Middle Eastern cohort of newly diagnosed CLL patients seen at the Kuwait Cancer Control Center (n = 300). Compared to Western studies, these Middle Eastern patients were diagnosed at a younger age (median of 59) and had a higher comorbidity burden (69% non-low risk CLL-CI). A higher CLL-CI score was independently associated with significantly shorter event-free survival and greater risk of death. Our analysis demonstrates that CLL-CI is a valuable tool for comorbidity assessment and prognostic influence in (relatively young) Middle Eastern CLL patients.