Abstract：
Lung cancer stands as a formidable global health challenge, necessitating innovative therapeutic strategies. Polyphenols, bioactive compounds synthesized by plants, have garnered attention for their diverse health benefits, particularly in combating various cancers, including lung cancer. The advent of whole-genome and transcriptome sequencing technologies has illuminated the pivotal roles of long noncoding RNAs (lncRNAs), operating at epigenetic, transcriptional, and posttranscriptional levels, in cancer progression. This review comprehensively explores the impact of polyphenols on both oncogenic and tumor-suppressive lncRNAs in lung cancer, elucidating on their intricate regulatory mechanisms. The comprehensive examination extends to the potential synergies when combining polyphenols with conventional treatments like chemotherapy, radiation, and immunotherapy. Recognizing the heterogeneity of lung cancer subtypes, the review emphasizes the need for the integration of nanotechnology for optimized polyphenol delivery and personalized therapeutic approaches. In conclusion, we collect the latest research, offering a holistic overview of the evolving landscape of polyphenol-mediated modulation of lncRNAs in lung cancer therapy. The integration of polyphenols and lncRNAs into multidimensional treatment strategies holds promise for enhancing therapeutic efficacy and navigating the challenges associated with lung cancer treatment.
摘要：
肺癌是一个巨大的全球健康挑战，需要创新的治疗策略。多酚,植物合成的生物活性化合物，他们多样化的健康益处引起了人们的关注，特别是在对抗各种癌症方面，包括肺癌.全基因组和转录组测序技术的出现阐明了长链非编码RNA（lncRNAs）的关键作用，在表观遗传下运作，转录，和转录后水平，在癌症进展中。这篇综述全面探讨了多酚对肺癌中致癌和抑癌lncRNAs的影响。阐明其复杂的调节机制。当将多酚与常规治疗如化疗相结合时，全面的检查延伸到潜在的协同作用，辐射,和免疫疗法。认识到肺癌亚型的异质性，该综述强调需要整合纳米技术以优化多酚递送和个性化治疗方法。总之,我们收集最新的研究，全面概述了肺癌治疗中多酚介导的lncRNAs调节的演变。多酚和lncRNAs整合到多维治疗策略中有望提高治疗效果并应对与肺癌治疗相关的挑战。
