Abstract：
Dopamine and prolactin are the key mediators involved in sexual function in both males and females, but the role of dopamine in female sexual dysfunction (FSD) is still unclear. The aim was to investigate the possible role of dopamine and their relationship with sex steroid hormones (estrogen, progesterone and dehydroepiandrosterone; DHEA) and prolactin levels in Egyptian women suffering from sexual dysfunction. This study included 84 women having sexual dysfunction (FSD group) and 84 normal sexual function (control group). All women were subjected to the questionnaire to assess their demographic and gynecological data as well as female sexual function index (FSFI). Blood samples were collected from all women for measuring serum estradiol, progesterone, DHEA, prolactin and dopamine levels. FSD patients had significantly higher serum progesterone and DHEA and prolactin levels; while significantly lower dopamine and estradiol levels versus controls (p < 0.001). In all women, dopamine level appeared as a predictor of FSD at cut-off point ≤8.8 ng/mL with sensitivity (75%), specificity (92%) and accuracy (83%) (p < 0.001). The low levels of dopamine were associated with significantly higher prevalence in patients with low estradiol (p < 0.001) and high progesterone (p < 0.001), DHEA (p < 0.001) and prolactin (p = 0.004). Also, dopamine was significantly positive correlation with arousal score (r = 0.16, p = 0.04), and negative correlation with age (r = -0.31, p < 0.001), pain score (r = -0.19, p = 0.01), DHEA (r = -0.45, p < 0.001) and prolactin (r = -0.28, p < 0.001). Low serum dopamine level is a potential diagnostic biomarker in women\'s sexual dysfunction and their association with high prolactin and sex steroid hormones dysfunction.
摘要：
多巴胺和催乳素是男性和女性参与性功能的关键介质，但多巴胺在女性性功能障碍（FSD）中的作用尚不清楚。目的是研究多巴胺的可能作用及其与性类固醇激素（雌激素，患有性功能障碍的埃及妇女的孕酮和脱氢表雄酮；DHEA）和催乳素水平。这项研究包括84名性功能障碍的女性（FSD组）和84名正常性功能的女性（对照组）。对所有妇女进行问卷调查，以评估其人口统计学和妇科数据以及女性性功能指数（FSFI）。收集所有女性的血样测定血清雌二醇,黄体酮,DHEA,催乳素和多巴胺水平.FSD患者的血清孕酮和DHEA和催乳素水平明显较高；而多巴胺和雌二醇水平明显低于对照组（p<0.001）。在所有的女人中,多巴胺水平在临界点≤8.8ng/mL时作为FSD的预测因子，灵敏度为75%，特异性(92%)和准确性(83%)(p<0.001)。低水平的多巴胺与低雌二醇（p<0.001）和高孕酮（p<0.001）患者的患病率显着升高。DHEA(p<0.001)和催乳素(p=0.004)。此外，多巴胺与觉醒评分呈显著正相关(r=0.16,p=0.04),与年龄呈负相关(r=-0.31，p<0.001)，疼痛评分（r=-0.19，p=0.01），DHEA(r=-0.45,p<0.001)和催乳素(r=-0.28,p<0.001)。低血清多巴胺水平是女性性功能障碍及其与高催乳素和性类固醇激素功能障碍的潜在诊断生物标志物。
