Abstract：
Zinc (Zn) is an essential trace element that is required for various biological functions, but excessive exposure to Zn is associated with many disorders and even diseases. However, the health effects and underlying mechanisms of long-term and high concentration exposure of Zn remain to be unclear. In the present study, we investigated the association between occupational exposure to Zn and liver function indicators (like alanine aminotransferase (ALT)) in workers. We found a positive association between Zn exposure and ALT level in workers. Workers having higher blood Zn (7735.65 (1159.15) μg/L) shows a 30.4 % increase in ALT level compared to those with lower blood Zn (5969.30 (989.26) μg/L). Furthermore, we explored the effects of phospholipids (PLs) and their metabolism on ALT level and discovered that Zn exposure in workers was associated with changes in PL levels and metabolism, which had further effects on increased ALT levels in workers. The study provides insights into the relationship between occupational Zn exposure and liver function, highlights the risk of long-term exposure to high concentrations of Zn, and paves the way for understanding the underlying mechanisms of Zn exposure on human health.
摘要：
锌（Zn）是一种必需的微量元素，是必需的各种生物功能，但是过度接触锌与许多疾病甚至疾病有关。然而,长期高浓度锌暴露对健康的影响和潜在机制仍不清楚.在本研究中,我们调查了职业锌暴露与工人肝功能指标(如丙氨酸转氨酶(ALT))之间的关联.我们发现工人的锌暴露与ALT水平呈正相关。与血锌含量较低（5969.30（989.26）μg/L）的工人相比，血锌含量较高（7735.65（1159.15）μg/L）的工人的ALT水平增加了30.4％。此外，我们探索了磷脂（PLs）及其代谢对ALT水平的影响，并发现工人的锌暴露与PL水平和代谢的变化有关。这对工人ALT水平的增加有进一步的影响。这项研究提供了对职业锌暴露与肝功能之间关系的见解，强调了长期暴露于高浓度锌的风险，为了解锌暴露对人体健康的潜在机制铺平了道路。
