PDF(Pubmed)
Abstract：
The available evidence on vitamin K status in cystic fibrosis (CF) is scarce, lacking data on vitamin K2 (menaquinones-MK). Therefore, we assessed vitamin K1, MK-4 and MK-7 concentrations (LC-MS/MS) in 63 pancreatic insufficient and modulator naïve CF patients, and compared to 61 healthy subjects (HS). Vitamin K1 levels did not differ between studied groups. MK-4 concentrations were higher (median <1st-3rd quartile>: 0.778 <0.589-1.086> vs. 0.349 <0.256-0.469>, p < 0.0001) and MK-7 levels lower (0.150 <0.094-0.259> vs. 0.231 <0.191-0.315>, p = 0.0007) in CF patients than in HS. MK-7 concentrations were higher in CF patients receiving K1 and MK-7 supplementation than in those receiving vitamin K1 alone or no supplementation. Moreover, vitamin K1 concentrations depended on the supplementation regime. Based on multivariate logistic regression analysis, we have found that MK-7 supplementation dose has been the only predictive factor for MK-7 levels. In conclusion, vitamin K1 levels in CF are low if not currently supplemented. MK-4 concentrations in CF patients supplemented with large doses of vitamin K1 are higher than in HS. MK-7 levels in CF subjects not receiving MK-7 supplementation, with no regard to vitamin K1 supplementation, are low. There do not seem to be any good clinical predictive factors for vitamin K status.
摘要：
囊性纤维化（CF）中维生素K状态的现有证据很少，缺乏维生素K2（甲基萘醌-MK）的数据。因此,我们评估了63例胰腺功能不足和调节剂初治CF患者的维生素K1，MK-4和MK-7浓度（LC-MS/MS），并与61名健康受试者(HS)进行比较。维生素K1水平在研究组之间没有差异。MK-4浓度更高（中位数<1-3四分位数>：0.778<0.589-1.086>vs.0.349<0.256-0.469>，p<0.0001）和MK-7水平较低（0.150<0.094-0.259>与0.231<0.191-0.315>，CF患者的p=0.0007）比HS患者。接受K1和MK-7补充的CF患者的MK-7浓度高于单独或不接受维生素K1补充的患者。此外，维生素K1的浓度取决于补充方案。基于多元逻辑回归分析，我们发现MK-7补充剂量是MK-7水平的唯一预测因素.总之,如果目前不补充，CF中的维生素K1水平很低。补充大剂量维生素K1的CF患者的MK-4浓度高于HS。未接受MK-7补充的CF受试者的MK-7水平，不考虑补充维生素K1，很低。似乎没有任何良好的维生素K状态的临床预测因素。
