Abstract：
BACKGROUND: We aimed to investigate the prevalence of skin disease among patients with systemic lupus erythematosus (SLE) and determine whether LE skin disease had clinical or serologic correlates with SLE.
METHODS: We reviewed records of 335 patients with SLE (seen at Mayo Clinic, Rochester, Minnesota, USA) and abstracted skin manifestations, fulfilled mucocutaneous SLE criteria, and clinical and serologic parameters.
RESULTS: Of the 231 patients with skin manifestations, 57 (24.7%) had LE-specific conditions, 102 (44.2%) had LE-nonspecific conditions, and 72 (31.2%) had both. LE skin disease was associated with photosensitivity, anti-Smith antibodies, and anti-U1RNP antibodies (all P < 0.001). Patients without LE skin disease more commonly had elevated C-reactive protein levels (P = 0.01). Patients meeting 2-4 mucocutaneous American College of Rheumatology criteria less commonly had cytopenia (P = 0.004) or anti-double-stranded DNA antibodies (P = 0.004). No significant associations were observed for systemic involvement (renal, hematologic, neurologic, and arthritis) when comparing patients with or without LE skin involvement. LE skin involvement was not significantly associated with internal SLE disease flare, number of medications, or overall survival.
CONCLUSIONS: LE skin disease commonly occurs in patients with SLE. The presence of LE skin disease had no mitigating impact on the severity of SLE sequelae, disease flares, number of medications, or overall survival.
METHODS: We reviewed records of 335 patients with SLE (seen at Mayo Clinic, Rochester, Minnesota, USA) and abstracted skin manifestations, fulfilled mucocutaneous SLE criteria, and clinical and serologic parameters.
RESULTS: Of the 231 patients with skin manifestations, 57 (24.7%) had LE-specific conditions, 102 (44.2%) had LE-nonspecific conditions, and 72 (31.2%) had both. LE skin disease was associated with photosensitivity, anti-Smith antibodies, and anti-U1RNP antibodies (all P < 0.001). Patients without LE skin disease more commonly had elevated C-reactive protein levels (P = 0.01). Patients meeting 2-4 mucocutaneous American College of Rheumatology criteria less commonly had cytopenia (P = 0.004) or anti-double-stranded DNA antibodies (P = 0.004). No significant associations were observed for systemic involvement (renal, hematologic, neurologic, and arthritis) when comparing patients with or without LE skin involvement. LE skin involvement was not significantly associated with internal SLE disease flare, number of medications, or overall survival.
CONCLUSIONS: LE skin disease commonly occurs in patients with SLE. The presence of LE skin disease had no mitigating impact on the severity of SLE sequelae, disease flares, number of medications, or overall survival.
摘要：
背景：我们旨在调查系统性红斑狼疮（SLE）患者中皮肤病的患病率，并确定LE皮肤病是否与SLE具有临床或血清学相关性。
方法：我们回顾了335例SLE患者的记录（在梅奥诊所，罗切斯特,明尼苏达,美国)和抽象的皮肤表现，符合粘膜皮肤SLE标准，以及临床和血清学参数。
结果：在231例有皮肤表现的患者中，57（24.7%）有LE特定条件，102例（44.2%）有LE非特定条件，和72（31.2％）两者都有。LE皮肤病与光敏性有关，抗史密斯抗体，和抗U1RNP抗体（所有P<0.001）。没有LE皮肤病的患者更常见的是C反应蛋白水平升高（P=0.01）。符合2-4例粘膜皮肤美国风湿病学会标准的患者较少出现血细胞减少症（P=0.004）或抗双链DNA抗体（P=0.004）。未观察到全身受累的显著关联(肾，血液学，神经学，和关节炎）比较有或没有LE皮肤受累的患者。LE皮肤受累与内部SLE疾病发作无关，药物的数量,或总体生存率。
结论：LE皮肤病常见于SLE患者。LE皮肤病的存在对SLE后遗症的严重程度没有减轻影响，疾病耀斑，药物的数量,或总体生存率。
方法：我们回顾了335例SLE患者的记录（在梅奥诊所，罗切斯特,明尼苏达,美国)和抽象的皮肤表现，符合粘膜皮肤SLE标准，以及临床和血清学参数。
结果：在231例有皮肤表现的患者中，57（24.7%）有LE特定条件，102例（44.2%）有LE非特定条件，和72（31.2％）两者都有。LE皮肤病与光敏性有关，抗史密斯抗体，和抗U1RNP抗体（所有P<0.001）。没有LE皮肤病的患者更常见的是C反应蛋白水平升高（P=0.01）。符合2-4例粘膜皮肤美国风湿病学会标准的患者较少出现血细胞减少症（P=0.004）或抗双链DNA抗体（P=0.004）。未观察到全身受累的显著关联(肾，血液学，神经学，和关节炎）比较有或没有LE皮肤受累的患者。LE皮肤受累与内部SLE疾病发作无关，药物的数量,或总体生存率。
结论：LE皮肤病常见于SLE患者。LE皮肤病的存在对SLE后遗症的严重程度没有减轻影响，疾病耀斑，药物的数量,或总体生存率。
