Abstract：
Quantifying the amount of proteinuria is mandatory in various disease conditions. The aim of this study was to study whether the spot urine protein-creatinine ratio (P-CR) correlates well with 24-h urinary total protein (UTP). The research hypothesis was that spot urine P-CR would correlate well with 24-h UTP. This was a cross-sectional, single-center study conducted in a tertiary care hospital. The spot urinary P-CR and 24-h urinary protein were determined from 70 patients with persistent glomerular proteinuria. This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (>3.5 g/day). Random spot urine P-CR correlated well with the 24-h UTP, particularly at lower levels of protein excretion.
摘要：
在各种疾病状况下,定量蛋白尿的量是强制性的。这项研究的目的是研究斑点尿蛋白-肌酐比率（P-CR）是否与24小时尿总蛋白（UTP）密切相关。研究假设是，斑点尿液P-CR将与24小时UTP良好相关。这是一个横截面，在三级医院进行的单中心研究。从70例持续性肾小球蛋白尿患者中测定了点尿P-CR和24小时尿蛋白。这项研究包括2-83岁的尼泊尔患者，平均年龄36.56岁（标准差：20.78）。男性的数量略高于女性，男女比例为1.26:1。44.3%的患者出现高血压,20%的患者出现糖尿病，74.3%的患者患有各种原因的急性肾小球肾炎,12.9%的患者患有慢性肾脏病。斑点尿P-CR与24小时UTP之间存在线性关系，相关系数为0.877(P<0.01)。在较高的蛋白质排泄水平（>3.5g/天）时，相关性欠佳。随机斑点尿P-CR与24小时UTP相关性良好，特别是在蛋白质排泄水平较低时。
