Abstract：
BACKGROUND: Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) and is a leading cause of vision loss. Early detection of DR-related neurodegenerative changes is crucial for effective management and prevention of vision loss in diabetic patients.
METHODS: In this study, we employed spectral-domain polarization-sensitive optical coherence tomography (SD PS-OCT) to assess retinal nerve fiber layer (RNFL) changes in 120 eyes from 60 types 1 DM patients without clinical DR and 60 age-matched healthy controls. Visual field testing was performed to evaluate mean sensitivity (MS) and mean defect (MD) as indicators of visual function.
RESULTS: SD PS-OCT measurements revealed significant reductions in RNFL birefringence, retardation, and thickness in type 1 DM patients compared to healthy controls. Visual field testing showed decreased MS and increased MD in DM patients, indicating functional impairment correlated with RNFL alterations.
CONCLUSIONS: Our findings demonstrate early neurodegenerative changes in the RNFL of type 1 DM patients without clinical DR, highlighting the potential of SD PS-OCT as a sensitive tool for early detection of subclinical DR-related neurodegeneration. These results underscore the importance of regular ophthalmic screenings in diabetic patients to enable timely intervention and prevent vision-threatening complications.
METHODS: In this study, we employed spectral-domain polarization-sensitive optical coherence tomography (SD PS-OCT) to assess retinal nerve fiber layer (RNFL) changes in 120 eyes from 60 types 1 DM patients without clinical DR and 60 age-matched healthy controls. Visual field testing was performed to evaluate mean sensitivity (MS) and mean defect (MD) as indicators of visual function.
RESULTS: SD PS-OCT measurements revealed significant reductions in RNFL birefringence, retardation, and thickness in type 1 DM patients compared to healthy controls. Visual field testing showed decreased MS and increased MD in DM patients, indicating functional impairment correlated with RNFL alterations.
CONCLUSIONS: Our findings demonstrate early neurodegenerative changes in the RNFL of type 1 DM patients without clinical DR, highlighting the potential of SD PS-OCT as a sensitive tool for early detection of subclinical DR-related neurodegeneration. These results underscore the importance of regular ophthalmic screenings in diabetic patients to enable timely intervention and prevent vision-threatening complications.
摘要：
背景：糖尿病性视网膜病变（DR）是糖尿病（DM）的常见并发症，并且是视力丧失的主要原因。早期发现DR相关的神经退行性变化对于有效管理和预防糖尿病患者的视力丧失至关重要。
方法：在本研究中，我们采用谱域偏振敏感光学相干断层扫描(SDPS-OCT)评估了来自60例无临床DR的1型DM患者和60例年龄匹配的健康对照者的120只眼的视网膜神经纤维层(RNFL)变化.进行视野测试以评估作为视觉功能指标的平均灵敏度（MS）和平均缺陷（MD）。
结果：SDPS-OCT测量显示RNFL双折射显著降低，延迟,与健康对照相比，1型DM患者的厚度。视野测试显示DM患者的MS减少和MD增加，表明功能损害与RNFL改变相关。
结论：我们的研究结果表明，没有临床DR的1型DM患者的RNFL早期神经退行性改变，强调SDPS-OCT作为早期检测亚临床DR相关神经变性的敏感工具的潜力。这些结果强调了糖尿病患者定期眼科筛查的重要性，以便能够及时干预并预防威胁视力的并发症。
方法：在本研究中，我们采用谱域偏振敏感光学相干断层扫描(SDPS-OCT)评估了来自60例无临床DR的1型DM患者和60例年龄匹配的健康对照者的120只眼的视网膜神经纤维层(RNFL)变化.进行视野测试以评估作为视觉功能指标的平均灵敏度（MS）和平均缺陷（MD）。
结果：SDPS-OCT测量显示RNFL双折射显著降低，延迟,与健康对照相比，1型DM患者的厚度。视野测试显示DM患者的MS减少和MD增加，表明功能损害与RNFL改变相关。
结论：我们的研究结果表明，没有临床DR的1型DM患者的RNFL早期神经退行性改变，强调SDPS-OCT作为早期检测亚临床DR相关神经变性的敏感工具的潜力。这些结果强调了糖尿病患者定期眼科筛查的重要性，以便能够及时干预并预防威胁视力的并发症。
