Abstract：
A crucial pathogenic mechanism in many bacterial diseases is the ability to create biofilms. Biofilms are suspected to play a role in over 80 % of microbial illnesses in humans. In light of the critical requirement for efficient management of bacterial infections, researchers have explored alternative techniques for treating bacterial disorders. One of the most promising ways to address this issue is through the development of long-lasting coatings with antibacterial properties. In recent years, antibacterial treatments based on metallic nanoparticles (NPs) have emerged as an effective strategy in the fight over bacterial drug resistance. Zinc oxide nanoparticles (ZnO-NPs) are the basis of a new composite coating material. This article begins with a brief overview of the mechanisms that underlie bacterial resistance to antimicrobial drugs. A detailed examination of the properties of metallic nanoparticles (NPs) and their potential use as antibacterial drugs for curing drug-sensitive and resistant bacteria follows. Furthermore, we assess metal nanoparticles (NPs) as powerful agents to fight against antibiotic-resistant bacteria and the growth of biofilm, and we look into their potential toxicological effects for the development of future medicines.
摘要：
许多细菌性疾病中的关键致病机制是产生生物膜的能力。生物膜被怀疑在人类超过80%的微生物疾病中起作用。鉴于有效管理细菌感染的关键要求，研究人员已经探索了治疗细菌疾病的替代技术。解决这一问题的最有希望的方法之一是开发具有抗菌性能的长效涂料。近年来,基于金属纳米粒子（NPs）的抗菌治疗已成为对抗细菌耐药性的有效策略。氧化锌纳米粒子(ZnO-NPs)是新型复合涂层材料的基础。本文首先简要概述了细菌对抗菌药物耐药的机制。下面详细检查金属纳米颗粒（NPs）的性质及其作为抗菌药物用于治疗药物敏感和耐药细菌的潜在用途。此外，我们评估金属纳米粒子（NPs）作为对抗抗生素抗性细菌和生物膜生长的强大药物，我们研究它们对未来药物开发的潜在毒理学影响。
