Abstract：
OBJECTIVE: Morning glory disc anomaly (MGDA) is a rare congenital ophthalmologic disorder. Historically it has been diagnosed fundoscopically, with little in the literature regarding its imaging findings. The purpose of this study is to further characterize the orbital and associated intracranial magnetic resonance imaging (MRI) findings of MGDA in our tertiary pediatric center.
METHODS: A retrospective review was performed of fundoscopically-diagnosed cases of MGDA, that had been referred for MRI. All MRI studies were scrutinized for orbital and other intracranial abnormalities known to occur in association with MGDA.
RESULTS: 18 of 19 cases of MGDA showed three characteristic MRI findings: funnel-shaped morphology of the posterior optic disc, abnormal soft tissue associated with the retrobulbar optic nerve, and effacement of adjacent subarachnoid spaces. The ipsilateral (intraorbital) optic nerve was larger in one patient and smaller in six. The ipsilateral optic chiasm was larger in two patients and smaller in one.
CONCLUSIONS: This study represents a comprehensive radiological-led investigation into MGDA. It describes the most frequently-encountered MRI findings in MGDA and emphasizes the importance of MRI in this cohort, i.e., in distinguishing MGDA from other posterior globe abnormalities, in assessing the visual pathway, and in screening for associated intracranial abnormalities - skull base/cerebral, vascular, and facial. It hypothesizes neurocristopathy as an underlying cause of MGDA and its associations. Caliber abnormalities of the ipsilateral optic nerve and chiasm are a frequent finding in MGDA. Optic pathway enlargement should not be labeled \"glioma\". (239/250).
METHODS: A retrospective review was performed of fundoscopically-diagnosed cases of MGDA, that had been referred for MRI. All MRI studies were scrutinized for orbital and other intracranial abnormalities known to occur in association with MGDA.
RESULTS: 18 of 19 cases of MGDA showed three characteristic MRI findings: funnel-shaped morphology of the posterior optic disc, abnormal soft tissue associated with the retrobulbar optic nerve, and effacement of adjacent subarachnoid spaces. The ipsilateral (intraorbital) optic nerve was larger in one patient and smaller in six. The ipsilateral optic chiasm was larger in two patients and smaller in one.
CONCLUSIONS: This study represents a comprehensive radiological-led investigation into MGDA. It describes the most frequently-encountered MRI findings in MGDA and emphasizes the importance of MRI in this cohort, i.e., in distinguishing MGDA from other posterior globe abnormalities, in assessing the visual pathway, and in screening for associated intracranial abnormalities - skull base/cerebral, vascular, and facial. It hypothesizes neurocristopathy as an underlying cause of MGDA and its associations. Caliber abnormalities of the ipsilateral optic nerve and chiasm are a frequent finding in MGDA. Optic pathway enlargement should not be labeled \"glioma\". (239/250).
摘要：
目的：牵牛花椎间盘异常（MGDA）是一种罕见的先天性眼科疾病。从历史上看，它是通过眼底诊断的，关于其成像发现的文献很少。这项研究的目的是在我们的三级儿科中心进一步表征MGDA的眼眶和相关的颅内磁共振成像（MRI）发现。
方法：对眼底诊断为MGDA的病例进行了回顾性分析，已被转诊为MRI。对所有MRI研究进行了仔细检查，以确定与MGDA相关的眼眶和其他颅内异常。
结果：19例MGDA患者中的18例表现为三种特征性的MRI表现：后视盘的漏斗状形态，与球后视神经相关的异常软组织，和相邻的蛛网膜下腔消失。一名患者的同侧（眶内）视神经较大，六名患者的视神经较小。同侧视神经交叉在两名患者中较大，而在一名患者中较小。
结论：这项研究代表了对MGDA的全面放射学主导调查。它描述了MGDA中最常见的MRI发现，并强调了MRI在该队列中的重要性。即，在区分MGDA与其他后地球异常时，在评估视觉通路时，并筛查相关的颅内异常-颅底/大脑，血管,和面部。它假设神经疾病是MGDA及其关联的潜在原因。同侧视神经和交叉的口径异常是MGDA的常见发现。视路扩大不应标记为“神经胶质瘤”。（239/250）。
方法：对眼底诊断为MGDA的病例进行了回顾性分析，已被转诊为MRI。对所有MRI研究进行了仔细检查，以确定与MGDA相关的眼眶和其他颅内异常。
结果：19例MGDA患者中的18例表现为三种特征性的MRI表现：后视盘的漏斗状形态，与球后视神经相关的异常软组织，和相邻的蛛网膜下腔消失。一名患者的同侧（眶内）视神经较大，六名患者的视神经较小。同侧视神经交叉在两名患者中较大，而在一名患者中较小。
结论：这项研究代表了对MGDA的全面放射学主导调查。它描述了MGDA中最常见的MRI发现，并强调了MRI在该队列中的重要性。即，在区分MGDA与其他后地球异常时，在评估视觉通路时，并筛查相关的颅内异常-颅底/大脑，血管,和面部。它假设神经疾病是MGDA及其关联的潜在原因。同侧视神经和交叉的口径异常是MGDA的常见发现。视路扩大不应标记为“神经胶质瘤”。（239/250）。
