Abstract：
Biomolecular condensation has gained considerable attention as a fundamental mechanism in cell signaling and various biological processes. A recent study by Egger et al. provides valuable insights into the constituents of topoisomerase IIβ binding protein 1 (TopBP1) condensates and sheds light on the mechanism of Chk1 activation by ataxia telangiectasia-mutated and Rad3-related (ATR) at the interface of these condensates.
摘要：
生物分子缩合作为细胞信号传导和各种生物过程中的基本机制已经得到了广泛的关注。Egger等人最近的一项研究。提供了对拓扑异构酶IIβ结合蛋白1（TopBP1）缩合物成分的有价值的见解，并揭示了这些缩合物界面处的共济失调毛细血管扩张突变和Rad3相关（ATR）激活Chk1的机制。
