通过中尺度 TopBP1 冷凝物照亮 ATR / Chk1 。
关键词: ATR Chk1 TopBP1 biomolecular condensate
Mesh : Ataxia Telangiectasia Mutated Proteins / metabolism Checkpoint Kinase 1 / metabolism Humans DNA-Binding Proteins / metabolism Carrier Proteins / metabolism Cell Cycle Proteins / metabolism Protein Kinases / metabolism Nuclear Proteins / metabolism Animals Protein Serine-Threonine Kinases / metabolism Signal Transduction
来 源: DOI:10.1016/j.tcb.2024.04.002