%0 Journal Article
%T Lighting ATR/Chk1 by mesoscale TopBP1 condensates.
%A Qin Y
%A Shi L
%J Trends Cell Biol
%V 34
%N 6
%D 2024 Jun 6
%M 38714421
%F 21.167
%R 10.1016/j.tcb.2024.04.002
%X Biomolecular condensation has gained considerable attention as a fundamental mechanism in cell signaling and various biological processes. A recent study by Egger et al. provides valuable insights into the constituents of topoisomerase IIβ binding protein 1 (TopBP1) condensates and sheds light on the mechanism of Chk1 activation by ataxia telangiectasia-mutated and Rad3-related (ATR) at the interface of these condensates.