{Reference Type}: Journal Article
{Title}: Lighting ATR/Chk1 by mesoscale TopBP1 condensates.
{Author}: Qin Y;Shi L;
{Journal}: Trends Cell Biol
{Volume}: 34
{Issue}: 6
{Year}: 2024 Jun 6
{Factor}: 21.167
{DOI}: 10.1016/j.tcb.2024.04.002
{Abstract}: Biomolecular condensation has gained considerable attention as a fundamental mechanism in cell signaling and various biological processes. A recent study by Egger et al. provides valuable insights into the constituents of topoisomerase IIβ binding protein 1 (TopBP1) condensates and sheds light on the mechanism of Chk1 activation by ataxia telangiectasia-mutated and Rad3-related (ATR) at the interface of these condensates.