PDF(Pubmed)
Abstract：
BACKGROUND: The human cerebellum emerges as a posterior brain structure integrating neural networks for sensorimotor, cognitive, and emotional processing across the lifespan. Developmental studies of the cerebellar anatomy and function are scant. We examine age-dependent MRI morphometry of the anterior cerebellar vermis, lobules I-V and posterior neocortical lobules VI-VII and their relationship to sensorimotor and cognitive functions.
METHODS: Typically developing children (TDC; n=38; age 9-15) and healthy adults (HAC; n=31; 18-40) participated in high-resolution MRI. Rigorous anatomically informed morphometry of the vermis lobules I-V and VI-VII and total brain volume (TBV) employed manual segmentation computer-assisted FreeSurfer Image Analysis Program [http://surfer.nmr.mgh.harvard.edu]. The neuropsychological scores (WASI-II) were normalized and related to volumes of anterior, posterior vermis, and TBV.
RESULTS: TBVs were age independent. Volumes of I-V and VI-VII were significantly reduced in TDC. The ratio of VI-VII to I-V (∼60%) was stable across age-groups; I-V correlated with visual-spatial-motor skills; VI-VII with verbal, visual-abstract and FSIQ.
CONCLUSIONS: In TDC neither anterior I-V nor posterior VI-VII vermis attained adult volumes. The \"inverted U\" developmental trajectory of gray matter peaking in adolescence does not explain this finding. The hypothesis of protracted development of oligodendrocyte/myelination is suggested as a contributor to TDC\'s lower cerebellar vermis volumes.
METHODS: Typically developing children (TDC; n=38; age 9-15) and healthy adults (HAC; n=31; 18-40) participated in high-resolution MRI. Rigorous anatomically informed morphometry of the vermis lobules I-V and VI-VII and total brain volume (TBV) employed manual segmentation computer-assisted FreeSurfer Image Analysis Program [http://surfer.nmr.mgh.harvard.edu]. The neuropsychological scores (WASI-II) were normalized and related to volumes of anterior, posterior vermis, and TBV.
RESULTS: TBVs were age independent. Volumes of I-V and VI-VII were significantly reduced in TDC. The ratio of VI-VII to I-V (∼60%) was stable across age-groups; I-V correlated with visual-spatial-motor skills; VI-VII with verbal, visual-abstract and FSIQ.
CONCLUSIONS: In TDC neither anterior I-V nor posterior VI-VII vermis attained adult volumes. The \"inverted U\" developmental trajectory of gray matter peaking in adolescence does not explain this finding. The hypothesis of protracted development of oligodendrocyte/myelination is suggested as a contributor to TDC\'s lower cerebellar vermis volumes.
摘要：
背景：人类小脑作为整合感觉运动神经网络的后脑结构出现，认知，和整个生命周期的情感处理。小脑解剖结构和功能的发展研究很少。我们检查了小脑前疣的年龄依赖性MRI形态学，小叶I-V和后新皮质小叶VI-VII及其与感觉运动和认知功能的关系。
方法：通常发育中的儿童（TDC；n=38；9-15岁）和健康成人（HAC；n=31；18-40）参与高分辨率MRI。使用手动分割计算机辅助FreeSurfer图像分析程序[http://surfer。nmr.mgh.哈佛。edu].神经心理学评分（WASI-II）被标准化，并与前牙体积相关，后疣,TBV。
结果：TBV与年龄无关。TDC中I-V和VI-VII的体积显著减少。VI-VII与I-V的比率（〜60％）在年龄组中是稳定的；I-V与视觉空间运动技能相关；VI-VII与口头，视觉抽象和FSIQ。
结论：在TDC中，前I-V和后VI-VII疣均未达到成人体积。青春期灰质高峰的“倒U”发育轨迹并不能解释这一发现。少突胶质细胞/髓鞘形成的长期发育假说被认为是TDC小脑疣体积降低的一个原因。
方法：通常发育中的儿童（TDC；n=38；9-15岁）和健康成人（HAC；n=31；18-40）参与高分辨率MRI。使用手动分割计算机辅助FreeSurfer图像分析程序[http://surfer。nmr.mgh.哈佛。edu].神经心理学评分（WASI-II）被标准化，并与前牙体积相关，后疣,TBV。
结果：TBV与年龄无关。TDC中I-V和VI-VII的体积显著减少。VI-VII与I-V的比率（〜60％）在年龄组中是稳定的；I-V与视觉空间运动技能相关；VI-VII与口头，视觉抽象和FSIQ。
结论：在TDC中，前I-V和后VI-VII疣均未达到成人体积。青春期灰质高峰的“倒U”发育轨迹并不能解释这一发现。少突胶质细胞/髓鞘形成的长期发育假说被认为是TDC小脑疣体积降低的一个原因。
