PDF(Pubmed)
Abstract：
Statin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.
摘要：
他汀类药物诱导的免疫介导的坏死性肌病（IMNM）是一种炎性肌病，可表现为近端肌无力，在某些情况下,吞咽困难和呼吸窘迫。在这份报告中,我们介绍了一例他汀类药物诱导的IMNM在一名78岁男性中的病例.患者在入院前10个月开始服用20mg阿托伐他汀后，肌酸酐激酶和肌红蛋白尿症的水平明显较高，近端肌肉逐渐无力1个月。高剂量糖皮质激素与甲氨蝶呤联合使用可观察到快速的临床改善。
