{Reference Type}: Case Reports
{Title}: Statin-induced, immune-mediated necrotising myopathy triggered by malignancy successfully treated with immunosuppression.
{Author}: Abouelazm A;Philops K;Amine A;Golam Y;
{Journal}: Clin Med (Lond)
{Volume}: 24
{Issue}: 3
{Year}: 2024 May 6
{Factor}: 5.41
{DOI}: 10.1016/j.clinme.2024.100217
{Abstract}: Statin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.