Abstract：
Due to their capacity to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for the formation of various types of protein-RNA complexes. The functions of IDRs are strongly modulated by post-translational modifications (PTMs). Phosphorylation is the most common and well-studied modification of IDRs, which can alter homomeric or heteromeric interactions of proteins and impact their ability to phase separate. Moreover, phosphorylation can influence the RNA-binding properties of proteins, and recent studies demonstrated its selective impact on the global profiles of protein-RNA binding and regulation. These findings highlight the need for further integrative approaches to understand how signalling remodels protein-RNA networks in cells.
摘要：
由于它们介导重复蛋白质相互作用的能力，内在无序区域（IDR）对于各种类型的蛋白质-RNA复合物的形成至关重要。IDR的功能受到翻译后修饰(PTM)的强烈调节。磷酸化是IDR最常见和研究最充分的修饰，这可以改变蛋白质的同聚或异聚相互作用，并影响它们相分离的能力。此外，磷酸化可以影响蛋白质的RNA结合特性，和最近的研究表明，它对蛋白质-RNA结合和调控的全局谱的选择性影响。这些发现强调了进一步整合方法的需要，以了解信号如何重塑细胞中的蛋白质-RNA网络。
