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Abstract：
OBJECTIVE: To assess the relationship between the change of optic disc vessel density (ODVD) and retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) patients.
METHODS: Retrospective case series.
METHODS: For 105 POAG patients, ≥5 consecutive optical coherence tomography (OCT) and OCT angiography images were obtained during ≥2 years of follow-up. Based on enface OCT angiography imaging, ODVD was calculated as the ratio of pixels occupied by vessels below the internal limiting membrane within the temporal area of the optic cup, and ODVD reduction was determined when there was a statistically significant negative slope (P < .05) for any of the global, superior, or inferior sectors. The association between the rates of ODVD change and RNFL thinning was assessed by a multivariable longitudinal linear mixed-effects model versus time.
RESULTS: During 2.9 ± 0.3 years of follow-up on the 105 participants with visual field mean deviation at baseline of -5.7 ± 4.8 dB, 46 (43.8%) showed ODVD reduction. Faster global RNFL thinning was associated with the smaller Bruch\'s membrane opening area (ß = 0.381; 95% confidence interval [CI], 0.120-0.646; P = .006), optic disc hemorrhage (ß = -0.567; 95% CI, -0.909 to -0.228; P = .002), and faster rate of global ODVD change (ß = -0.090; 95% CI, -0.139 to -0.042; P = .001).
CONCLUSIONS: Reduction of optic disc microvasculature was associated with rapid RNFL thinning in POAG. This suggests a role for deep optic nerve head circulation in the glaucoma pathogenesis.
METHODS: Retrospective case series.
METHODS: For 105 POAG patients, ≥5 consecutive optical coherence tomography (OCT) and OCT angiography images were obtained during ≥2 years of follow-up. Based on enface OCT angiography imaging, ODVD was calculated as the ratio of pixels occupied by vessels below the internal limiting membrane within the temporal area of the optic cup, and ODVD reduction was determined when there was a statistically significant negative slope (P < .05) for any of the global, superior, or inferior sectors. The association between the rates of ODVD change and RNFL thinning was assessed by a multivariable longitudinal linear mixed-effects model versus time.
RESULTS: During 2.9 ± 0.3 years of follow-up on the 105 participants with visual field mean deviation at baseline of -5.7 ± 4.8 dB, 46 (43.8%) showed ODVD reduction. Faster global RNFL thinning was associated with the smaller Bruch\'s membrane opening area (ß = 0.381; 95% confidence interval [CI], 0.120-0.646; P = .006), optic disc hemorrhage (ß = -0.567; 95% CI, -0.909 to -0.228; P = .002), and faster rate of global ODVD change (ß = -0.090; 95% CI, -0.139 to -0.042; P = .001).
CONCLUSIONS: Reduction of optic disc microvasculature was associated with rapid RNFL thinning in POAG. This suggests a role for deep optic nerve head circulation in the glaucoma pathogenesis.
摘要：
目的：评估原发性开角型青光眼（POAG）患者视盘血管密度（ODVD）变化与视网膜神经纤维层（RNFL）变薄的关系。
方法：回顾性病例系列。
方法：对于105名POAG患者，在≥2年的随访期间，获得了≥5个连续的光学相干断层扫描（OCT）和OCT血管造影（OCTA）图像。基于正面OCTA成像，ODVD被计算为在光学杯的时间区域内内部限制膜下方的血管所占据的像素的比率。和ODVD减少时，有一个统计学上显著的负斜率（P<0.05）的任何全球，上级,或劣等部门。通过多变量纵向线性混合效应模型与ODVD变化率与RNFL变薄之间的关联进行了评估。时间。
结果：在对105名参与者进行2.9±0.3年的随访期间，基线视野平均偏差为5.7±4.8dB，46（43.8%）显示ODVD减少。更快的全局RNFL变薄与更小的布鲁赫膜开口面积相关(β=0.381;95%置信区间(CI),0.120至0.646；P=0.006），视盘出血(β=-0.567;95%CI,-0.909~-0.228;P=0.002)和更快的整体ODVD变化率(β=-0.090;95%CI,-0.139~-0.042;P=0.001)。
结论：视盘微血管减少与POAG中快速RNFL变薄有关。这表明深层ONH循环在青光眼发病机理中的作用。
方法：回顾性病例系列。
方法：对于105名POAG患者，在≥2年的随访期间，获得了≥5个连续的光学相干断层扫描（OCT）和OCT血管造影（OCTA）图像。基于正面OCTA成像，ODVD被计算为在光学杯的时间区域内内部限制膜下方的血管所占据的像素的比率。和ODVD减少时，有一个统计学上显著的负斜率（P<0.05）的任何全球，上级,或劣等部门。通过多变量纵向线性混合效应模型与ODVD变化率与RNFL变薄之间的关联进行了评估。时间。
结果：在对105名参与者进行2.9±0.3年的随访期间，基线视野平均偏差为5.7±4.8dB，46（43.8%）显示ODVD减少。更快的全局RNFL变薄与更小的布鲁赫膜开口面积相关(β=0.381;95%置信区间(CI),0.120至0.646；P=0.006），视盘出血(β=-0.567;95%CI,-0.909~-0.228;P=0.002)和更快的整体ODVD变化率(β=-0.090;95%CI,-0.139~-0.042;P=0.001)。
结论：视盘微血管减少与POAG中快速RNFL变薄有关。这表明深层ONH循环在青光眼发病机理中的作用。
