Abstract：
Inflammation represents the inherent protective reaction of the human body to various harmful agents and noxious stimuli. Standard anti-inflammatory therapy including nonsteroidal anti-inflammatory drugs are associated with several side effects. In the past decades, people rely on medicinal plants for the treatment of inflammation. The traditional utilization of medicinal plants is regarded as a safe, cost-effective, and broadly accepted approach. In this study, anti-inflammatory activity of plants traditionally utilized by the D\'harawal people in Australia has been assessed in vitro. Eighty Australian native plants were screened based on the Dharawal Pharmacopeia for their inhibitory effect on the nitric oxide (NO) production in lipopolysaccharides (LPS) and interferon (IFN)-γ stimulated RAW 264.7 murine macrophages for their anti-inflammatory activity. From the eighty ethanolic extracts screened, seventeen displayed potent NO inhibition with an IC50 recorded below 15 μg/mL. The aim of this review was to utilise the ethnopharmacological knowledge and to correlate the anti-inflammatory activity of the seventeen plants with either their known or unknown phytochemicals reported in the literature. In doing so, we have created a snapshot of Australian native plant candidates that warrant further chemical investigation associated with their anti-inflammatory activity.
摘要：
炎症代表人体对各种有害物质和有害刺激的固有保护性反应。包括非甾体抗炎药在内的标准抗炎治疗与几种副作用有关。在过去的几十年里，人们依靠药用植物治疗炎症。传统的药用植物利用被认为是安全的,成本效益高,和广泛接受的方法。在这项研究中,已在体外评估了澳大利亚D\'harawal人传统上使用的植物的抗炎活性。根据Dharawal药典筛选了80种澳大利亚本地植物，它们对脂多糖（LPS）和干扰素（IFN）-γ刺激的RAW264.7鼠巨噬细胞中一氧化氮（NO）产生的抑制作用具有抗炎活性。从筛选的80种乙醇提取物中，17显示出有效的NO抑制作用，IC50记录为低于15μg/mL。这篇综述的目的是利用民族药理学知识，并将十七种植物的抗炎活性与文献中报道的已知或未知的植物化学物质相关联。在这样做的时候，我们创建了澳大利亚本土植物候选物的快照,这些植物候选物需要进一步进行与其抗炎活性相关的化学研究.
