PDF(Pubmed)
Abstract：
In mammals, gonadal somatic cell lineage differentiation determines the development of the bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the spermatogenic tubules, support spermatogenesis during gonadal development. During embryonic Sertoli cell lineage differentiation, relevant genes, including WT1, GATA4, SRY, SOX9, AMH, PTGDS, SF1, and DMRT1, are expressed at specific times and in specific locations to ensure the correct differentiation of the embryo toward the male phenotype. The dysregulated development of Sertoli cells leads to gonadal malformations and male fertility disorders. Nevertheless, the molecular pathways underlying the embryonic origin of Sertoli cells remain elusive. By reviewing recent advances in research on embryonic Sertoli cell genesis and its key regulators, this review provides novel insights into sex determination in male mammals as well as the molecular mechanisms underlying the genealogical differentiation of Sertoli cells in the male reproductive ridge.
摘要：
在哺乳动物中,性腺体细胞谱系分化决定了双潜能性腺发育为卵巢或睾丸。支持细胞,生精小管中唯一的体细胞，在性腺发育过程中支持精子发生。在胚胎支持细胞系分化过程中，相关基因，包括WT1，GATA4，SRY，SOX9AMH,PTGDS,SF1和DMRT1在特定时间和特定位置表达，以确保胚胎正确分化为雄性表型。支持细胞的发育失调导致性腺畸形和男性生育障碍。然而，支持细胞胚胎起源的分子途径仍然难以捉摸。通过综述胚胎支持细胞发生及其关键调控因子的研究进展,这篇综述提供了有关雄性哺乳动物性别决定以及雄性生殖脊中支持细胞谱系分化的分子机制的新见解。
