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Abstract：
Previous studies have shown that a higher intensity of physical activity (PA) is associated with a lower risk of cognitive impairment (CI), whereas hypertension is associated with higher CI. However, there are few studies on the association between PA intensity and cognitive function in hypertensive patients. This study investigated the association between PA intensity and cognitive function in hypertensive patients. A total of 2035 hypertensive patients were included in this study, including 407 hypertensive patients with CI and 1628 hypertensive patients with normal cognitive function matched 1:4 by age and sex. The International Physical Activity Questionnaire-Long Form and the Mini-mental State Examination were used to evaluate PA intensity, total metabolic equivalents, and cognitive function in patients with hypertension. Multivariate logistic regression was used to analyze the correlation between PA intensity and CI in hypertensive patients. The Spearman correlation coefficient was used to analyze the correlation between PA intensity and the total score of each component of the MMSE and the correlation between PA total metabolic equivalents and cardiac structure in hypertensive patients. After adjusting for all confounding factors, PA intensity was negatively associated with CI in hypertensive patients (OR = 0.608, 95% CI: 0.447-0.776, P < 0.001), and this association was also observed in hypertensive patients with education level of primary school and below and junior high school and above (OR = 0.732, 95% CI: 0.539-0.995, P = 0.047; OR = 0.412, 95% CI: 0.272-0.626, P < 0.001). The intensity of PA in hypertensive patients was positively correlated with orientation (r = 0.125, P < 0.001), memory (r = 0.052, P = 0.020), attention and numeracy (r = 0.151, P < 0.001), recall ability (r = 0.110, P < 0.001), and language ability (r = 0.144, P < 0.001). PA total metabolic equivalents in hypertensive patients were negatively correlated with RVEDD and LAD (r = - 0.048, P = 0.030; r = - 0.051, P = 0.020) and uncorrelated with LVEDD (r = 0.026, P = 0.233). Higher PA intensity reduced the incidence of CI in hypertensive patients. Therefore, hypertensive patients were advised to moderate their PA according to their circumstances.
摘要：
先前的研究表明，较高强度的体力活动（PA）与较低的认知障碍（CI）风险相关。而高血压与高CI相关。然而,关于高血压患者PA强度与认知功能之间关系的研究很少。这项研究调查了高血压患者PA强度与认知功能之间的关系。总共2035名高血压患者被纳入这项研究，包括407名合并CI的高血压患者和1628名认知功能正常的高血压患者，按年龄和性别1:4匹配。国际身体活动问卷-长形式和小型精神状态检查用于评估PA强度，总代谢当量，高血压患者的认知功能。采用多因素logistic回归分析高血压患者PA强度与CI的相关性。采用Spearman相关系数分析高血压患者PA强度与MMSE各组分总分的相关性及PA总代谢当量与心脏结构的相关性。在调整了所有混杂因素后，高血压患者PA强度与CI呈负相关(OR=0.608,95%CI:0.447～0.776,P<0.001)。在文化程度为小学及以下，初中及以上的高血压患者中也观察到了这种相关性（OR=0.732，95％CI：0.539-0.995，P=0.047；OR=0.412，95％CI：0.272-0.626，P<0.001）。高血压患者PA强度与定位呈正相关(r=0.125,P<0.001),记忆(r=0.052,P=0.020),注意力和算术(r=0.151，P<0.001)，召回能力(r=0.110,P<0.001),语言能力(r=0.144,P<0.001)。高血压患者PA总代谢当量与RVEDD、LAD呈负相关(r=-0.048,P=0.030;r=-0.051,P=0.020),与LVEDD呈负相关(r=0.026,P=0.233)。较高的PA强度降低了高血压患者CI的发生率。因此,建议高血压患者根据自己的情况调节PA.
