Abstract：
Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.
摘要：
在肥胖相关的2型糖尿病（T2D）中，解决胰岛素分泌过多和胰岛素抵抗的上游是具有挑战性的。这里,我们考虑了糖尿病母亲胎儿胰岛素分泌和作用的动力学。我们认为胎儿胰岛素分泌过多首先发生，胰岛素抵抗是一种适应性保护性反应。
