PDF(Pubmed)
Abstract：
Subacute sclerosing panencephalitis (SSPE) is a fatal disorder that occurs as a rare complication of childhood measles. Symptoms typically manifest between the ages of 5 and 15. While the incidence of SSPE is declining globally, it is still prevalent in regions where measles remains common and vaccination rates are low due to poverty and lack of health education. Diagnosing SSPE can be challenging, particularly when patients exhibit unusual symptoms. A thorough clinical evaluation, including vaccination history, physical examination, electroencephalogram (EEG) and Cerebrospinal fluid (CSF) analysis, can help in making a diagnosis. We present the case of a young woman in her early 20s who initially experienced depressive symptoms, followed by myoclonus, dementia and visual impairment. The patient was ultimately diagnosed with SSPE based on characteristic EEG findings, neuroimaging results, CSF analysis and elevated serum measles antibody levels.
摘要：
亚急性硬化性全脑炎（SSPE）是一种致命疾病，是儿童麻疹的罕见并发症。症状通常在5至15岁之间出现。虽然SSPE的发病率在全球范围内下降，在麻疹仍然很常见的地区，由于贫困和缺乏健康教育，疫苗接种率很低。诊断SSPE可能具有挑战性，特别是当患者表现出异常症状时。全面的临床评估，包括疫苗接种史,体检,脑电图（EEG）和脑脊液（CSF）分析，可以帮助做出诊断。我们介绍了一个20岁出头的年轻女性，她最初经历了抑郁症状，其次是肌阵挛症,痴呆和视力障碍。患者最终根据特征性脑电图结果诊断为SSPE，神经影像学检查结果，CSF分析和血清麻疹抗体水平升高。
