Mdm1 - Il22 - Ifng 基因座中的 CTCF 结合位点可形成细胞因子表达谱 , 并在早期 Th1 细胞命运确定中起关键作用。
关键词: CBSs CTCF Hi-C Th1 Th17 Toxoplasma gondii interferon-gamma interleukin-22 lymphocytic choriomeningitis virus natural killer cells super-enhancers three-dimensional topologically associating domains
Mesh : Animals CCCTC-Binding Factor / metabolism genetics Th1 Cells / immunology Mice Cell Differentiation / immunology Interferon-gamma / metabolism Binding Sites Interleukins / metabolism genetics Interleukin-22 Enhancer Elements, Genetic / genetics Mice, Inbred C57BL Chromatin / metabolism Toxoplasmosis / immunology parasitology genetics Gene Expression Regulation Toxoplasma / immunology Cytokines / metabolism Cell Lineage Th17 Cells / immunology
来 源:
DOI:10.1016/j.immuni.2024.04.007
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