PDF(Pubmed)
Abstract：
BACKGROUND: Familial hypercholesterolaemia (FH) is an autosomal dominant inherited disorder of lipid metabolism and a preventable cause of premature cardiovascular disease. Current detection rates for this highly treatable condition are low. Early detection and management of FH can significantly reduce cardiac morbidity and mortality. This study aims to implement a primary-tertiary shared care model to improve detection rates for FH. The primary objective is to evaluate the implementation of a shared care model and support package for genetic testing of FH. This protocol describes the design and methods used to evaluate the implementation of the shared care model and support package to improve the detection of FH.
METHODS: This mixed methods pre-post implementation study design will be used to evaluate increased detection rates for FH in the tertiary and primary care setting. The primary-tertiary shared care model will be implemented at NSW Health Pathology and Sydney Local Health District in NSW, Australia, over a 12-month period. Implementation of the shared care model will be evaluated using a modification of the implementation outcome taxonomy and will focus on the acceptability, evidence of delivery, appropriateness, feasibility, fidelity, implementation cost and timely initiation of the intervention. Quantitative pre-post and qualitative semistructured interview data will be collected. It is anticipated that data relating to at least 62 index patients will be collected over this period and a similar number obtained for the historical group for the quantitative data. We anticipate conducting approximately 20 interviews for the qualitative data.
BACKGROUND: Ethical approval has been granted by the ethics review committee (Royal Prince Alfred Hospital Zone) of the Sydney Local Health District (Protocol ID: X23-0239). Findings will be disseminated through peer-reviewed publications, conference presentations and an end-of-study research report to stakeholders.
METHODS: This mixed methods pre-post implementation study design will be used to evaluate increased detection rates for FH in the tertiary and primary care setting. The primary-tertiary shared care model will be implemented at NSW Health Pathology and Sydney Local Health District in NSW, Australia, over a 12-month period. Implementation of the shared care model will be evaluated using a modification of the implementation outcome taxonomy and will focus on the acceptability, evidence of delivery, appropriateness, feasibility, fidelity, implementation cost and timely initiation of the intervention. Quantitative pre-post and qualitative semistructured interview data will be collected. It is anticipated that data relating to at least 62 index patients will be collected over this period and a similar number obtained for the historical group for the quantitative data. We anticipate conducting approximately 20 interviews for the qualitative data.
BACKGROUND: Ethical approval has been granted by the ethics review committee (Royal Prince Alfred Hospital Zone) of the Sydney Local Health District (Protocol ID: X23-0239). Findings will be disseminated through peer-reviewed publications, conference presentations and an end-of-study research report to stakeholders.
摘要：
背景：家族性高胆固醇血症（FH）是一种常染色体显性遗传的脂质代谢障碍，是过早心血管疾病的可预防原因。这种高度可治疗的疾病的当前检测率很低。FH的早期检测和管理可以显着降低心脏病发病率和死亡率。本研究旨在实施一级-三级共享护理模式，以提高FH的检出率。主要目标是评估用于FH基因测试的共享护理模型和支持包的实施情况。该协议描述了用于评估共享护理模型和支持包的实现以改善FH检测的设计和方法。
方法：实施后研究设计的混合方法将用于评估三级和初级保健环境中FH检出率的提高。初三共享护理模式将在新南威尔士州健康病理学和新南威尔士州悉尼地方卫生区实施，澳大利亚,在12个月的时间里。将使用对实施结果分类的修改来评估共享护理模式的实施，并将侧重于可接受性，交货证据,适当性，可行性,保真度，实施成本和及时启动干预措施。将收集定量的pre-post和定性的半结构化访谈数据。预期在这段时间内将收集与至少62个指标患者相关的数据,并且对于定量数据的历史组获得相似的数量。我们预计将对定性数据进行大约20次访谈。
背景：悉尼地方卫生区的伦理审查委员会（皇家阿尔弗雷德王子医院区）已获得伦理批准（协议ID：X23-0239）。调查结果将通过同行评审的出版物传播，会议演讲和向利益相关者提交的研究结束研究报告。
方法：实施后研究设计的混合方法将用于评估三级和初级保健环境中FH检出率的提高。初三共享护理模式将在新南威尔士州健康病理学和新南威尔士州悉尼地方卫生区实施，澳大利亚,在12个月的时间里。将使用对实施结果分类的修改来评估共享护理模式的实施，并将侧重于可接受性，交货证据,适当性，可行性,保真度，实施成本和及时启动干预措施。将收集定量的pre-post和定性的半结构化访谈数据。预期在这段时间内将收集与至少62个指标患者相关的数据,并且对于定量数据的历史组获得相似的数量。我们预计将对定性数据进行大约20次访谈。
背景：悉尼地方卫生区的伦理审查委员会（皇家阿尔弗雷德王子医院区）已获得伦理批准（协议ID：X23-0239）。调查结果将通过同行评审的出版物传播，会议演讲和向利益相关者提交的研究结束研究报告。
