METHODS: We have employed a bacterial culture-based observational cohort design in this study. Two groups, formalin disinfection and non-formalin group, both underwent systematic 12-core TRB. In the formalin group, the biopsy needle tip was immersed in 10% formalin solution after each core, while in the non-formalin group, no formalin solution immersion was used. The primary outcomes include bacterial growth on biopsy needle tips and post-biopsy infective events.
RESULTS: Formalin disinfection significantly reduced bacterial growth on needle tips (P <.001). The formalin group had no post-biopsy infections or sepsis, while the non-formalin group experienced a 7.5% infective event rate after TRB.
CONCLUSIONS: Formalin disinfection of biopsy needle tip significantly reduces bacterial growth on biopsy needle and urinary tract infectious complications developed secondary to TRB. Further multicenter randomized controlled studies with larger cohorts are warranted to validate and establish formalin disinfection as a routine practice in TRB procedures.
方法:我们在本研究中采用了基于细菌培养的观察队列设计。两组,福尔马林消毒和非福尔马林组,两者都经历了系统的12核TRB。在福尔马林组中,活检针尖在每个核心后浸入10%福尔马林溶液中,而在非福尔马林组中不使用福尔马林溶液浸渍。主要结果包括活检针尖上的细菌生长和活检后感染事件。
结果:福尔马林消毒可显着降低针尖上的细菌生长(p<0.001)。福尔马林组没有活检后感染或败血症,而非福尔马林组TRB后感染性事件发生率为7.5%。
结论:福尔马林对活检针尖的消毒可明显减少活检针上的细菌生长和TRB继发的尿路感染并发症。需要更多的多中心随机对照研究,以验证和建立福尔马林消毒作为TRB程序的常规做法。