PRMT1 促进与胰腺癌获得性化学耐药相关的表观遗传重编程。
关键词: BACH1 CP: Cancer MAFF PRMT1 chemoresistance epigenetic reprogramming pancreatic cancer
Mesh : Protein-Arginine N-Methyltransferases / metabolism genetics Humans Drug Resistance, Neoplasm / genetics Epigenesis, Genetic Pancreatic Neoplasms / genetics drug therapy pathology Gemcitabine Deoxycytidine / analogs & derivatives pharmacology therapeutic use Repressor Proteins / metabolism genetics Cell Line, Tumor Animals Mice Carcinoma, Pancreatic Ductal / genetics drug therapy pathology Gene Expression Regulation, Neoplastic / drug effects Cellular Reprogramming / drug effects genetics
来 源:
DOI:10.1016/j.celrep.2024.114176
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