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Abstract：
BACKGROUND: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients.
METHODS: The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model.
RESULTS: Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients.
CONCLUSIONS: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.
METHODS: The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model.
RESULTS: Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients.
CONCLUSIONS: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.
摘要：
背景：这项研究的主要目的是确定冠状动脉疾病（CAD）患者中代谢功能障碍相关的脂肪肝（MAFLD）的危险因素。
方法：本回顾性队列研究是Pars队列研究（PCS）的一部分。参与者被归类为是否患有MAFLD。将患者的独立变量模式与没有MAFLD的患者进行比较。所有变量均保留在多变量逻辑回归模型中。
结果：完全，1862名CAD参与者参加了这项研究。在647名（40.1%）参与者中诊断出MAFLD。性别,糖尿病,高血压,烟草,鸦片,酒精,年龄,体重,腰围,胆固醇,HDL,甘油三酯，天冬氨酸转氨酶（AST），MAFLD和非MAFLD患者的丙氨酸转氨酶（ALT）差异有统计学意义。此外，多变量logistic回归分析结果显示,男性(OR=0.651,95%CI:0.470~0.902,P值=0.01)和鸦片消费(OR=0.563,95%CI:0.328~0.968,P值<0.001)是冠心病患者发生MAFLD的负危险因素.患有糖尿病（OR=2.414，95％CI：1.740-3.349，P值<0.001），高腰围(OR=1.078,95%CI:1.055~1.102,P值<0.01),高甘油三酯(OR=1.005,95%CI:1.001~1.008,P值=0.006),高ALT(OR=1.039,95%CI:1.026～1.051,P值<0.01)是冠心病患者MAFLD的危险因素。
结论：我们的研究发现，服用鸦片会降低CAD患者MAFLD的可能性，因为这些患者的食欲下降和体重指数（BMI）降低。另一方面,女性性别,患有糖尿病，高腰围,高甘油三酯水平，高ALT水平增加CAD患者MAFLD的概率。
方法：本回顾性队列研究是Pars队列研究（PCS）的一部分。参与者被归类为是否患有MAFLD。将患者的独立变量模式与没有MAFLD的患者进行比较。所有变量均保留在多变量逻辑回归模型中。
结果：完全，1862名CAD参与者参加了这项研究。在647名（40.1%）参与者中诊断出MAFLD。性别,糖尿病,高血压,烟草,鸦片,酒精,年龄,体重,腰围,胆固醇,HDL,甘油三酯，天冬氨酸转氨酶（AST），MAFLD和非MAFLD患者的丙氨酸转氨酶（ALT）差异有统计学意义。此外，多变量logistic回归分析结果显示,男性(OR=0.651,95%CI:0.470~0.902,P值=0.01)和鸦片消费(OR=0.563,95%CI:0.328~0.968,P值<0.001)是冠心病患者发生MAFLD的负危险因素.患有糖尿病（OR=2.414，95％CI：1.740-3.349，P值<0.001），高腰围(OR=1.078,95%CI:1.055~1.102,P值<0.01),高甘油三酯(OR=1.005,95%CI:1.001~1.008,P值=0.006),高ALT(OR=1.039,95%CI:1.026～1.051,P值<0.01)是冠心病患者MAFLD的危险因素。
结论：我们的研究发现，服用鸦片会降低CAD患者MAFLD的可能性，因为这些患者的食欲下降和体重指数（BMI）降低。另一方面,女性性别,患有糖尿病，高腰围,高甘油三酯水平，高ALT水平增加CAD患者MAFLD的概率。
