PDF(Pubmed)
Abstract：
Toxic leukoencephalopathy (TL) refers to damage to the brain white matter following exposure to toxic agents. Multiple agents are incriminated in this condition, including chemotherapy drugs. 5-Fluorouracil, widely used in oncology, is responsible for neurotoxicity in less than 5% of cases. We report the case of a 54-year-old male patient who presented with neurological symptoms following 5-FU-based chemotherapy for gastric adenocarcinoma, and whose MRI scan revealed signs suggestive of toxic leukoencephalopathy. We also report on the evolution of the abnormalities described on his MRI after 1 year.
摘要：
毒性白质脑病（TL）是指暴露于有毒物质后对脑白质的损害。多名特工在这种情况下被定罪，包括化疗药物.5-氟尿嘧啶,广泛用于肿瘤学，在不到5%的病例中导致神经毒性。我们报告了一名54岁的男性患者，该患者在基于5-FU的胃腺癌化疗后出现神经系统症状。MRI扫描显示有中毒性白质脑病的征象.我们还报告了1年后他的MRI上描述的异常的演变。
