%0 Case Reports
%T 5-Fluorouracil-induced acute leukoencephalopathy: Case report and literature review.
%A Ziani H
%A Nasri S
%A Kamaoui I
%A Skiker I
%J Radiol Case Rep
%V 19
%N 7
%D 2024 Jul
%M 38689804
暂无%R 10.1016/j.radcr.2024.03.064
%X Toxic leukoencephalopathy (TL) refers to damage to the brain white matter following exposure to toxic agents. Multiple agents are incriminated in this condition, including chemotherapy drugs. 5-Fluorouracil, widely used in oncology, is responsible for neurotoxicity in less than 5% of cases. We report the case of a 54-year-old male patient who presented with neurological symptoms following 5-FU-based chemotherapy for gastric adenocarcinoma, and whose MRI scan revealed signs suggestive of toxic leukoencephalopathy. We also report on the evolution of the abnormalities described on his MRI after 1 year.