{Reference Type}: Case Reports
{Title}: 5-Fluorouracil-induced acute leukoencephalopathy: Case report and literature review.
{Author}: Ziani H;Nasri S;Kamaoui I;Skiker I;
{Journal}: Radiol Case Rep
{Volume}: 19
{Issue}: 7
{Year}: 2024 Jul
暂无{DOI}: 10.1016/j.radcr.2024.03.064
{Abstract}: Toxic leukoencephalopathy (TL) refers to damage to the brain white matter following exposure to toxic agents. Multiple agents are incriminated in this condition, including chemotherapy drugs. 5-Fluorouracil, widely used in oncology, is responsible for neurotoxicity in less than 5% of cases. We report the case of a 54-year-old male patient who presented with neurological symptoms following 5-FU-based chemotherapy for gastric adenocarcinoma, and whose MRI scan revealed signs suggestive of toxic leukoencephalopathy. We also report on the evolution of the abnormalities described on his MRI after 1 year.