PDF(Pubmed)
Abstract：
We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby. During her pregnancy, she developed cytomegalovirus viraemia, gestational diabetes and pre-eclampsia. Here, we report the first combined use of cyclophosphamide, rituximab and intensified plasma exchange in anti-GBM disease in pregnancy, allowing minimal exposure to cytotoxic medication, resulting in live birth and dialysis independence.
摘要：
我们介绍了一名20多岁的孕妇的案例，该孕妇在孕中期因肾小球基底膜（GBM）疾病而出现严重的肺出血和透析依赖性急性肾功能衰竭。对治疗的反应，她恢复了肾功能并分娩了一个婴儿。在她怀孕期间,她患上了巨细胞病毒血症,妊娠期糖尿病和先兆子痫。这里,我们报道了环磷酰胺的首次联合使用，利妥昔单抗和强化血浆置换治疗妊娠期抗GBM疾病，允许最小的细胞毒性药物接触，导致活产和透析独立。
