Abstract：
Low-grade appendiceal mucinous neoplasms (LAMN) are very rare, accounting for approximately 0.2%-0.5% of gastrointestinal tumors. We conducted a multicenter retrospective study to explore the impact of different surgical procedures combined with HIPEC on the short-term outcomes and long-term survival of patients.
We retrospectively analyzed the clinicopathological data of 91 LAMN perforation patients from 9 teaching hospitals over a 10-year period, and divided them into HIPEC group and non-HIPEC group based on whether or not underwent HIPEC.
Of the 91 patients with LAMN, 52 were in the HIPEC group and 39 in the non-HIPEC group. The Kaplan-Meier method predicted that 52 patients in the HIPEC group had 5- and 10-year overall survival rates of 82.7% and 76.9%, respectively, compared with predicted survival rates of 51.3% and 46.2% for the 39 patients in the non-HIPEC group, with a statistically significant difference between the two groups (χ2 = 10.622, p = 0.001; χ2 = 10.995, p = 0.001). Compared to the 5-year and 10-year relapse-free survival rates of 75.0% and 65.4% in the HIPEC group, respectively, the 5-year and 10-year relapse-free survival rates of 48.7% and 46.2% in the non-HIPEC group were significant different between the two outcomes (χ2 = 8.063, p = 0.005; χ2 = 6.775, p = 0.009). The incidence of postoperative electrolyte disturbances and hypoalbuminemia was significantly higher in the HIPEC group than in the non-HIPEC group (p = 0.023; p = 0.044).
This study shows that surgery combined with HIPEC can significantly improve 5-year and 10-year overall survival rates and relapse-free survival rates of LAMN perforation patients, without affecting their short-term clinical outcomes.
We retrospectively analyzed the clinicopathological data of 91 LAMN perforation patients from 9 teaching hospitals over a 10-year period, and divided them into HIPEC group and non-HIPEC group based on whether or not underwent HIPEC.
Of the 91 patients with LAMN, 52 were in the HIPEC group and 39 in the non-HIPEC group. The Kaplan-Meier method predicted that 52 patients in the HIPEC group had 5- and 10-year overall survival rates of 82.7% and 76.9%, respectively, compared with predicted survival rates of 51.3% and 46.2% for the 39 patients in the non-HIPEC group, with a statistically significant difference between the two groups (χ2 = 10.622, p = 0.001; χ2 = 10.995, p = 0.001). Compared to the 5-year and 10-year relapse-free survival rates of 75.0% and 65.4% in the HIPEC group, respectively, the 5-year and 10-year relapse-free survival rates of 48.7% and 46.2% in the non-HIPEC group were significant different between the two outcomes (χ2 = 8.063, p = 0.005; χ2 = 6.775, p = 0.009). The incidence of postoperative electrolyte disturbances and hypoalbuminemia was significantly higher in the HIPEC group than in the non-HIPEC group (p = 0.023; p = 0.044).
This study shows that surgery combined with HIPEC can significantly improve 5-year and 10-year overall survival rates and relapse-free survival rates of LAMN perforation patients, without affecting their short-term clinical outcomes.
摘要：
背景：低级别阑尾黏液性肿瘤（LAMN）非常罕见，约占胃肠道肿瘤的0.2%-0.5%。我们进行了一项多中心回顾性研究，以探讨不同手术方式联合HIPEC对患者短期预后和长期生存率的影响。
方法：我们回顾性分析了来自9家教学医院的91例LAMN穿孔患者的临床病理资料，历时10年。根据是否接受HIPEC分为HIPEC组和非HIPEC组。
结果：在91例LAMN患者中，HIPEC组52例，非HIPEC组39例。Kaplan-Meier法预测HIPEC组52例患者5年和10年总生存率分别为82.7%和76.9%,分别,与非HIPEC组39例患者的51.3%和46.2%的预测生存率相比，两组间差异有统计学意义(χ2=10.622,p=0.001;χ2=10.995,p=0.001)。与HIPEC组的5年和10年无复发生存率75.0%和65.4%相比，分别,非HIPEC组的5年和10年无复发生存率分别为48.7%和46.2%,两组间差异有统计学意义(χ2=8.063,p=0.005;χ2=6.775,p=0.009).HIPEC组术后电解质紊乱和低蛋白血症的发生率明显高于非HIPEC组（p=0.023；p=0.044）。
结论：本研究表明，手术联合HIPEC可显著提高LAMN穿孔患者5年和10年总生存率和无复发生存率，而不影响其短期临床结果。
方法：我们回顾性分析了来自9家教学医院的91例LAMN穿孔患者的临床病理资料，历时10年。根据是否接受HIPEC分为HIPEC组和非HIPEC组。
结果：在91例LAMN患者中，HIPEC组52例，非HIPEC组39例。Kaplan-Meier法预测HIPEC组52例患者5年和10年总生存率分别为82.7%和76.9%,分别,与非HIPEC组39例患者的51.3%和46.2%的预测生存率相比，两组间差异有统计学意义(χ2=10.622,p=0.001;χ2=10.995,p=0.001)。与HIPEC组的5年和10年无复发生存率75.0%和65.4%相比，分别,非HIPEC组的5年和10年无复发生存率分别为48.7%和46.2%,两组间差异有统计学意义(χ2=8.063,p=0.005;χ2=6.775,p=0.009).HIPEC组术后电解质紊乱和低蛋白血症的发生率明显高于非HIPEC组（p=0.023；p=0.044）。
结论：本研究表明，手术联合HIPEC可显著提高LAMN穿孔患者5年和10年总生存率和无复发生存率，而不影响其短期临床结果。
