OBJECTIVE: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.
METHODS: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
RESULTS: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes.
CONCLUSIONS: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
目的:我们研究心脏代谢,饮食和生活方式参数对空腹和餐后GLP-1有风险的人,或者生活在一起,T2D。
方法:我们分析了来自两个创新药物倡议(IMI)糖尿病患者分层研究(DIRECT)队列的横截面数据,队列1(n=2127)有糖尿病风险的个体;队列2(n=789)新发T2D的个体。
结果:我们的多元回归分析显示,空腹总GLP-1与胰岛素抵抗表型相关,并观察到与男性有很强的独立关系,肥胖和肝脏脂肪增加,特别是在糖尿病前期人群中。相比之下,我们发现,随着血糖恶化,GLP-1的增量减少,肥胖程度较高,肝脏脂肪,糖尿病前期队列中男性和胰岛素敏感性降低。较高的空腹总GLP-1与低全麦摄入量有关,糖尿病前期患者的水果和蔬菜,糖尿病患者大量摄入红肉和酒精。
结论:这些研究为空腹和递增GLP-1、糖尿病代谢特征和肥胖之间的关联提供了新的见解。和饮食摄入量,并提出了有关空腹GLP-1在病理生理学T2D中的相关性的有趣问题。