PDF(Pubmed)
Abstract：
BACKGROUND: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.
OBJECTIVE: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.
METHODS: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
RESULTS: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes.
CONCLUSIONS: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
OBJECTIVE: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.
METHODS: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
RESULTS: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes.
CONCLUSIONS: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
摘要：
背景：胰高血糖素样肽-1（GLP-1）在2型糖尿病（T2D）和肥胖症中的作用尚未完全了解。
目的：我们研究心脏代谢，饮食和生活方式参数对空腹和餐后GLP-1有风险的人，或者生活在一起，T2D。
方法：我们分析了来自两个创新药物倡议（IMI）糖尿病患者分层研究（DIRECT）队列的横截面数据，队列1（n=2127）有糖尿病风险的个体；队列2（n=789）新发T2D的个体。
结果：我们的多元回归分析显示，空腹总GLP-1与胰岛素抵抗表型相关，并观察到与男性有很强的独立关系，肥胖和肝脏脂肪增加，特别是在糖尿病前期人群中。相比之下,我们发现，随着血糖恶化，GLP-1的增量减少，肥胖程度较高,肝脏脂肪,糖尿病前期队列中男性和胰岛素敏感性降低。较高的空腹总GLP-1与低全麦摄入量有关，糖尿病前期患者的水果和蔬菜，糖尿病患者大量摄入红肉和酒精。
结论：这些研究为空腹和递增GLP-1、糖尿病代谢特征和肥胖之间的关联提供了新的见解。和饮食摄入量，并提出了有关空腹GLP-1在病理生理学T2D中的相关性的有趣问题。
目的：我们研究心脏代谢，饮食和生活方式参数对空腹和餐后GLP-1有风险的人，或者生活在一起，T2D。
方法：我们分析了来自两个创新药物倡议（IMI）糖尿病患者分层研究（DIRECT）队列的横截面数据，队列1（n=2127）有糖尿病风险的个体；队列2（n=789）新发T2D的个体。
结果：我们的多元回归分析显示，空腹总GLP-1与胰岛素抵抗表型相关，并观察到与男性有很强的独立关系，肥胖和肝脏脂肪增加，特别是在糖尿病前期人群中。相比之下,我们发现，随着血糖恶化，GLP-1的增量减少，肥胖程度较高,肝脏脂肪,糖尿病前期队列中男性和胰岛素敏感性降低。较高的空腹总GLP-1与低全麦摄入量有关，糖尿病前期患者的水果和蔬菜，糖尿病患者大量摄入红肉和酒精。
结论：这些研究为空腹和递增GLP-1、糖尿病代谢特征和肥胖之间的关联提供了新的见解。和饮食摄入量，并提出了有关空腹GLP-1在病理生理学T2D中的相关性的有趣问题。
