PDF(Pubmed)
Abstract：
BACKGROUND: Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are all immune-mediated chronic inflammatory liver diseases. Autoimmune liver diseases are rare, making identification and treatment difficult. To improve clinical outcomes and enhance patient quality of life, we performed an epidemiological study of autoimmune liver diseases based on real-world comprehensive data.
RESULTS: We used National Health Insurance Service claims data in Korea from 2005 to 2019. Patients were identified using the International Classification of Disease 10th Revision code, and rare intractable disease codes assigned according to the strict diagnostic criteria. In the AIH cohort, 8,572 (83.9%) were females and the mean age at diagnosis was 56.3 ± 14.3 years. PBC also showed female dominance (83.3%) and the mean age was 57.8 ± 12.6 years. Patients with PSC showed no sex predominance and had a mean age of 57.8 ± 21.5 years. During the study period, there were 10,212, 6,784, and 888 AIH, PBC, and PSC patients, respectively. The prevalence of AIH, PBC, and PSC in 2019 were 18.4, 11.8, and 1.5 per 100,000 population, while the corresponding incidences were 2.3, 1.4, and 0.3 per 100,000 population, respectively. Analysis of sex-age-standardized data showed that the annual prevalence of these diseases is increasing. The 10-year survival rates were 89.8%, 74.9%, and 73.4% for AIH, PBC, and PSC, respectively.
CONCLUSIONS: The number of patients with autoimmune liver disease in South Korea is increasing over time. Further research on autoimmune liver disease is needed to fulfill unmet clinical needs.
RESULTS: We used National Health Insurance Service claims data in Korea from 2005 to 2019. Patients were identified using the International Classification of Disease 10th Revision code, and rare intractable disease codes assigned according to the strict diagnostic criteria. In the AIH cohort, 8,572 (83.9%) were females and the mean age at diagnosis was 56.3 ± 14.3 years. PBC also showed female dominance (83.3%) and the mean age was 57.8 ± 12.6 years. Patients with PSC showed no sex predominance and had a mean age of 57.8 ± 21.5 years. During the study period, there were 10,212, 6,784, and 888 AIH, PBC, and PSC patients, respectively. The prevalence of AIH, PBC, and PSC in 2019 were 18.4, 11.8, and 1.5 per 100,000 population, while the corresponding incidences were 2.3, 1.4, and 0.3 per 100,000 population, respectively. Analysis of sex-age-standardized data showed that the annual prevalence of these diseases is increasing. The 10-year survival rates were 89.8%, 74.9%, and 73.4% for AIH, PBC, and PSC, respectively.
CONCLUSIONS: The number of patients with autoimmune liver disease in South Korea is increasing over time. Further research on autoimmune liver disease is needed to fulfill unmet clinical needs.
摘要：
背景：自身免疫性肝炎（AIH），原发性胆汁性胆管炎(PBC),原发性硬化性胆管炎（PSC）均为免疫介导的慢性炎症性肝病。自身免疫性肝病很少见，使识别和治疗变得困难。为了改善临床结果并提高患者的生活质量，我们根据真实世界的综合数据对自身免疫性肝病进行了流行病学研究.
结果：我们使用了韩国2005年至2019年的国民健康保险服务索赔数据。使用国际疾病分类第10版代码识别患者，和根据严格的诊断标准分配的罕见疑难杂症代码。在AIH队列中，8,572（83.9％）为女性，诊断时的平均年龄为56.3±14.3岁。PBC还显示出女性优势（83.3％），平均年龄为57.8±12.6岁。PSC患者没有性别优势，平均年龄为57.8±21.5岁。在学习期间,有10,212,6,784和888AIH，PBC,和PSC患者，分别。AIH的患病率,PBC,2019年的PSC分别为每10万人口18.4、11.8和1.5，而相应的发病率为每10万人2.3、1.4和0.3，分别。对性别年龄标准化数据的分析表明，这些疾病的年患病率正在增加。10年生存率为89.8%,74.9%,AIH为73.4%，PBC,和PSC,分别。
结论：随着时间的推移，韩国自身免疫性肝病患者的数量在增加。需要进一步研究自身免疫性肝病以满足未满足的临床需求。
结果：我们使用了韩国2005年至2019年的国民健康保险服务索赔数据。使用国际疾病分类第10版代码识别患者，和根据严格的诊断标准分配的罕见疑难杂症代码。在AIH队列中，8,572（83.9％）为女性，诊断时的平均年龄为56.3±14.3岁。PBC还显示出女性优势（83.3％），平均年龄为57.8±12.6岁。PSC患者没有性别优势，平均年龄为57.8±21.5岁。在学习期间,有10,212,6,784和888AIH，PBC,和PSC患者，分别。AIH的患病率,PBC,2019年的PSC分别为每10万人口18.4、11.8和1.5，而相应的发病率为每10万人2.3、1.4和0.3，分别。对性别年龄标准化数据的分析表明，这些疾病的年患病率正在增加。10年生存率为89.8%,74.9%,AIH为73.4%，PBC,和PSC,分别。
结论：随着时间的推移，韩国自身免疫性肝病患者的数量在增加。需要进一步研究自身免疫性肝病以满足未满足的临床需求。
