Abstract：
N, N-diethyl-meta-toluamide (DEET) has been considered the \'gold standard\' for insect repellent use since the 1950s and constitutes most insect repellents on the market. However, conflicting data in the scientific literature and confusing information in the media are at the core of debates about the safety of DEET insect repellents for the protection of children against arthropod bites. The few fatal occurrences involving DEET insect repellents and complications of their use in the pediatric population are typically the result of accidental overdoses or misuse of insect repellents that disregard warnings on product labels. With appropriate application, the safety record of DEET insect repellents continues to be excellent with few side effects. The purpose of this review is to provide a summary of the literature on safety outcomes of DEET insect repellent use in children; outline the pediatric recommendations relating to DEET insect repellents; and provide an overview of EPA-approved and naturally derived alternatives to DEET that possess low toxicity while providing a similar level of protection to synthetic insect repellents.
摘要：
N,自1950年代以来，N-二乙基-间甲苯酰胺（DEET）一直被认为是用于驱虫剂的“黄金标准”，并且构成了市场上大多数驱虫剂。然而,科学文献中相互矛盾的数据和媒体中令人困惑的信息是关于DEET驱虫剂保护儿童免受节肢动物叮咬的安全性的辩论的核心。涉及DEET驱虫剂的少数致命事件及其在儿科人群中使用的并发症通常是由于意外过量或滥用驱虫剂而忽略了产品标签上的警告。通过适当的应用，DEET驱虫剂的安全记录仍然很好，副作用很少。这篇综述的目的是提供有关儿童使用DEET驱虫剂的安全性结果的文献摘要；概述与DEET驱虫剂有关的儿科建议；并概述EPA批准的天然来源的DEET替代品，这些替代品具有低毒性，同时提供与合成驱虫剂相似的保护水平。
