METHODS: This retrospective cohort study comprised 951 couples with FCPs and 10,788 couples with normal karyotypes who underwent IVF/ICSI treatment at Peking University Third Hospital between 2015 and 2021. The exposure was FCPs. The embryological outcomes and clinical outcomes were compared.
RESULTS: The FCPs, as a whole, compromised the oocyte maturation rate (76.0% vs. 78.8%, P = 0.008), while they did not adversely affect other IVF/ICSI outcomes. Further detailed analyses showed that every type of FCPs contributed to the lower oocyte maturation rate, particularly the rare FCPs (69.0% vs. 78.8%, P = 0.008). The female qh + was associated with a higher normal fertilization rate (63.0% vs. 59.2%, adjusted P = 0.022), a higher clinical pregnancy rate (37.0% vs. 30.7%, adjusted P = 0.048), and a higher live birth rate (27.0% vs.19.0%, adjusted P = 0.003) in couples undergoing IVF. Conversely, in couples undergoing ICSI, female qh + was found to be related to a lower normal fertilization rate (58.8% vs. 63.8%, P = 0.032), a comparable clinical pregnancy rate (25.7% vs. 30.9%, P = 0.289), and a comparable live birth rate (19.8% vs. 19.2%, P = 0.880) compared to the control group. Additionally, an increased risk of preterm birth was observed in women undergoing IVF with multiple polymorphisms (62.5% vs. 16.9%, adjusted P < 0.001) and in women undergoing ICSI with pstk+ (36.4% vs. 15.4%, P = 0.036).
CONCLUSIONS: Our research unravels the diverse impacts of various FCPs on IVF/ICSI outcomes, highlighting the detrimental effects of FCPs on oocyte maturation and the risk of preterm birth.
方法:这项回顾性队列研究包括2015年至2021年在北京大学第三医院接受IVF/ICSI治疗的951对FCP夫妇和10,788对正常核型夫妇。暴露是FCP。比较胚胎学结果和临床结果。
结果:FCP,作为一个整体,卵母细胞成熟率受损(76.0%vs.78.8%,P=0.008),而对其他IVF/ICSI结局无不良影响.进一步的详细分析表明,每种类型的FCP都有助于较低的卵母细胞成熟率,特别是罕见的FCP(69.0%vs.78.8%,P=0.008)。女性qh+与较高的正常受精率相关(63.0%vs.59.2%,调整后的P=0.022),更高的临床妊娠率(37.0%vs.30.7%,调整后的P=0.048),和更高的活产率(27.0%vs.19.0%,在接受IVF的夫妇中,调整后的P=0.003)。相反,在接受ICSI的夫妇中,发现女性qh+与较低的正常受精率有关(58.8%与63.8%,P=0.032),具有可比性的临床妊娠率(25.7%与30.9%,P=0.289),和可比的活产率(19.8%与19.2%,P=0.880)与对照组相比。此外,在接受IVF的女性中观察到早产风险增加,并伴有多种多态性(62.5%vs.16.9%,调整后的P<0.001)和接受ICSI伴pstk+的女性(36.4%vs.15.4%,P=0.036)。
结论:我们的研究揭示了各种FCP对IVF/ICSI结局的不同影响,强调FCP对卵母细胞成熟和早产风险的有害影响。